Thirteen new dolabrane-type diterpenoids, koilodenoids A-M (-), including a chlorinated congener (), along with six known analogues, were isolated from . The structures were determined by analysis of spectroscopic data, ECD spectra, and X-ray crystallographic studies. The absolute configuration of C-15 in the 15,16-diol unit of compounds and was established by using the dimolybdenum tetraacetate [Mo(AcO)]-induced ECD method. Compounds , , , , and showed moderate to significant immunosuppressive activities against the proliferation of T and B lymphocytes , with compound being the most potent (IC 0.86 and 0.29 μM, respectively).
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Dolabrane-Type Diterpenoids with Immunosuppressive Activity from .
J Nat Prod
June 2022
University of Chinese Academy of Science, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
Thirteen new dolabrane-type diterpenoids, koilodenoids A-M (-), including a chlorinated congener (), along with six known analogues, were isolated from . The structures were determined by analysis of spectroscopic data, ECD spectra, and X-ray crystallographic studies. The absolute configuration of C-15 in the 15,16-diol unit of compounds and was established by using the dimolybdenum tetraacetate [Mo(AcO)]-induced ECD method.
View Article and Find Full Text PDFDolabrane Diterpenoids from the Chinese Liverwort .
J Nat Prod
November 2021
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan 250012, People's Republic of China.
Nine new dolabrane-type diterpenoids, notoscarins A-I (-), including an unprecedented 6,18-cyclo-dolabrane-type diterpenoid () obtained through intramolecular cyclization, two rare 19--2-chloro-dolabrane diterpenoids ( and ), six new related dolabrane-type diterpenoids (-), and one new butyrolactone derivative (), were isolated from the Chinese liverwort . The 6,18-cyclo-dolabrane and 19--dolabrane carbon skeletons are reported for the first time. The structures of these compounds were determined on the basis of MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations.
View Article and Find Full Text PDFMangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.
Int J Cancer
December 2015
Tumorimmunology Program (D030), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Natural compounds are an important source for drug development. With an increasing cancer rate worldwide there is an urgent quest for new anti-cancer drugs. In this study, we show that a group of dolabrane-type of diterpenes, collectively named tagalsins, isolated from the Chinese mangrove genus Ceriops has potent cytotoxicity on a panel of hematologic cancer cells.
View Article and Find Full Text PDFDolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities.
Fitoterapia
June 2015
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China. Electronic address:
Chemical examination of the barks of mangrove plant Ceriops tagal resulted in the isolation of six new dolabrane-type diterpenes with the trivial names of tagalenes A-F (1-6), together with 10 known analogues. The structures of new compounds were elucidated by extensive spectroscopic data analyses. Tagalenes A-C (1-3) are characterized by 18-nordolabrane scaffold, while tagalene F (6) featured by a 2,3-seco dolabrane derivative.
View Article and Find Full Text PDFNotolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens.
J Nat Prod
September 2014
Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of the Ministry of Education, School of Pharmaceutical Science, Shandong University, Jinan 250012, People's Republic of China.
Ten new dolabrane-type diterpenoids, notolutesins A-J (1-10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confirmed by single-crystal X-ray crystallography. The absolute configuration of 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra.
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