AI Article Synopsis
- Previous research highlighted that lymphatic vessels encourage hair follicle growth by influencing dermal papilla cells, but the specific factors involved were unclear.
- This study aimed to identify paracrine factors from lymphatic endothelial cells and found that Sostdc1 is more abundant in these cells compared to blood vessel endothelial cells.
- The research demonstrated that Sostdc1 levels rise during the hair growth phase in mice and, when applied to dermal papilla cells, it boosts the expression of a key signaling molecule related to hair follicle development.
Article Abstract
In our previous study, we found that lymphatic vessels stimulate hair follicle growth through paracrine effects on dermal papilla cells. However, the paracrine factors secreted from cutaneous lymphatic vessels that can activate dermal papilla cells are still unknown. In this study, we investigated whether lymphatic endothelial cells might secrete paracrine factors that activate dermal papilla cells in vitro. We found that Sostdc1 was more expressed in lymphatic endothelial cells compared with blood vascular endothelial cells. In addition, Sostdc1 expression levels were significantly increased during the anagen phase in the back skin of C57BL/6J mice, as compared to the telogen phase. We also observed that incubation of dermal papilla cells with 200 ng/mL Sostdc1 for 72 h induced the expression levels of Lef-1, a downstream target of Wnt signaling. Taken together, our results reveal that Sostdc1, a BMP antagonist, secreted from cutaneous lymphatic vessels, may act as a paracrine factor for hair follicle growth.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164032 | PMC |
| http://dx.doi.org/10.3390/cimb44050146 | DOI Listing |
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