AI Article Synopsis
- Sarcoidosis is a rare inflammatory disease that can affect multiple organs and is linked to various factors, including infections and environmental exposures.
- There have been rare instances of sarcoid-like reactions and conditions such as erythema nodosum reported following COVID-19 vaccinations, although detailed investigations were limited.
- This case study describes a patient who developed sudden vision loss linked to sarcoidosis after receiving the COVID-19 vaccine, leading to a diagnosis confirmed by lung biopsy and treated with corticosteroids, though vision improvement was only partial after three months.
Article Abstract
Sarcoidosis is an idiopathic granulomatous disease and can virtually affect any organ system. Multiple factors, including tubercular antigens organic and environmental exposures, have been implicated in its pathogenesis. In addition to drugs, sarcoid-like reactions have been reported following varicella and influenza vaccination. Few reports of erythema nodosum and Lofgren syndrome have been reported after the COVID19 vaccination, though no histologic diagnosis was pursued in these cases. We herein report a case of sarcoidosis presenting with bilateral acute onset vision loss with a temporal association with COVID19 vaccination (ChadOx-1 n-COV, COVISHIELDTM). Symptoms started within two weeks of receiving the vaccine. Alternate causes for optic neuritis were excluded. Transbronchial lung biopsy showed the presence of non-caseating epithelioid cell granulomas. The patient received high-dose corticosteroids immediately after diagnosis, albeit with incomplete clinical improvement in vision on a three-month follow-up. In conclusion, we report a novel case of sarcoidosis-related optic neuritis following COVID19 vaccination.
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| http://dx.doi.org/10.4081/monaldi.2022.2279 | DOI Listing |
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