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Inconsistency between overall and subgroup analyses. | LitMetric

Inconsistency between overall and subgroup analyses.

Gen Psychiatr

Departments of Biostatistics & Computational Biology, University of Rochester, Rochester, New York, USA.

Published: May 2022

Suppose we have a sample of subjects in two treatment groups. To study the difference of the treatment effects, we can analyse the data using all subjects (overall analysis). We may also divide the subjects into several subgroups based on some covariates of interest (eg, gender), and study the treatment effects within each subgroup. The results of these two analyses may be different or even in opposite directions. In this paper, we give a general sufficient condition of consistency between the overall and subgroup analyses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114839PMC
http://dx.doi.org/10.1136/gpsych-2021-100732DOI Listing

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