A low-cost quantitative continuous measurement of movements utilizes accelerometers to generate signal outputs to precisely record the positions of extremities during the performance of movements. This procedure can readily be accomplished with inexpensive materials constructed indivisuals throughout the world. The proposed protocol provides the framework for trained raters to assess the signal outputs by visual observation to generate objective measurements like the measurements of the actual movements. Expert raters can then remotely give quantitative suggestions for providers in underserved regions to utilize precision medicine to develop optimal treatment plans tailored to the specific needs of each individual. The proposed protocol lays the foundations for experts located in tertiary centers to provide optimal assessments of signal outputs generated remotely in underserved regions. This protocol provides the means to address gaps in current research including the dearth of objective measurements of movements utilizing automatic intelligence and machine learning to accurately and precisely analyze movement assessments. Future research will include the development of robotic tools to perform assessments and analyses of the movements of human beings to enhance the conduct of movement evaluations of people with Parkinson's disease and related conditions to apply precision medicine for optimal diagnostic and therapeutic interventions.
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http://dx.doi.org/10.1016/j.mex.2022.101739 | DOI Listing |
Biophys J
January 2025
Department of Pharmacology, University of California Davis, California 95616.
In every heartbeat, cardiac muscle cells perform excitation-Ca signaling-contraction (EC) coupling to pump blood against the vascular resistance. Cardiomyocytes can sense the mechanical load and activate mechano-chemo-transduction (MCT) mechanism, which provides feedback regulation of EC coupling. MCT feedback is important for the heart to upregulate contraction in response to increased load to maintain cardiac output.
View Article and Find Full Text PDFNat Metab
January 2025
Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Interoception broadly refers to awareness of one's internal milieu. Although the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferent signalling and corresponding brain circuits that shape perception of the viscera are not entirely clear. Here, we use mice to parse neural circuits subserving interoception of the heart and gut.
View Article and Find Full Text PDFNat Commun
January 2025
Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Mediator25 (MED25) has been ascribed as a signal-processing and -integrating center that controls jasmonate (JA)-induced and MYC2-dependent transcriptional output. A better understanding of the regulation of MED25 stability will undoubtedly advance our knowledge of the precise regulation of JA signaling-related transcriptional output. Here, we report that Arabidopsis MED16 activates JA-responsive gene expression by promoting MED25 stability.
View Article and Find Full Text PDFAnal Chem
January 2025
Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China.
A sensitive fluorescence biosensor was developed for microcystin-LR (MC-LR) detection using H1, H2, and H3 DNA probes as sensing elements. The aptamer in H1 can recognize the target. H2 was labeled with FAM and BHQ.
View Article and Find Full Text PDFISA Trans
January 2025
School of Electrical Engineering, University of Jinan, Jinan, Shandong 250022, China. Electronic address:
This paper focuses on the issue of global practical tracking control by output feedback for uncertain nonlinear systems with unknown control coefficients and unknown reference signal. Unlike other tracking works, the upper and lower bounds of the unknown control coefficients in the studied nonlinear system are not required to be known, while the nonlinearities are bounded by the unmeasured states multiplying an unknown constant, the polynomial-of-output and the polynomial-of-input. Inspired by related works, an adaptive tracking controller based on a new dynamic high gain has been successfully constructed by combining the universal control idea and the concept of dead-zone with backstepping technique, which effectively handles the impacts of multiple uncertainties.
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