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http://dx.doi.org/10.1038/s41389-022-00408-4 | DOI Listing |
Mol Ther Methods Clin Dev
December 2024
Research Institute, Children's Hospital of Orange County, Orange, CA, USA.
Mucopolysaccharidosis type I (MPS I) is a metabolic disorder characterized by a deficiency in α-l-iduronidase (IDUA), leading to impaired glycosaminoglycan degradation. Current approved treatments seek to restore IDUA levels via enzyme replacement therapy (ERT) and/or hematopoietic stem cell transplantation (HSCT). The effectiveness of these treatment strategies in preventing neurodegeneration is limited due to the inability of ERT to penetrate the blood-brain barrier (BBB) and HSCT's limited CNS reconstitution of IDUA levels.
View Article and Find Full Text PDFCureus
December 2024
Vascular Surgery, Centro Médico Nacional 20 de Noviembre, Mexico City, MEX.
This case report evaluates current diagnostic and treatment approaches for intrapelvic acetabular migration, focusing on the rare but serious complication of acute limb ischemia following hip arthroplasty. A 67-year-old female with a history of total hip arthroplasty 10 years ago presented with acute limb ischemia after experiencing a traumatic event 72 hours prior, which had caused displacement of her hip prosthesis. Notably, she had a history of a traumatic event two years earlier for which she had been advised to undergo surgical correction, which she had refused.
View Article and Find Full Text PDFUltrasonics
December 2024
School of Mechatronic & Automation Engineering, Shanghai University, Shanghai 200444, China; Key Laboratory of Silicate Cultural Relics Conservation (Shanghai University), Ministry of Education, China. Electronic address:
Fiber reinforced polymer composites (FRPs) are essential for various industrial fields, but wrinkles inside will greatly reduce their mechanical properties. Full-matrix capture (FMC) is a popular data structure for ultrasonic phased array imaging in composites. However, such structure may lead to data redundancy and noise interference.
View Article and Find Full Text PDFCell Oncol (Dordr)
December 2024
Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.
Life Sci
December 2024
Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain; Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain. Electronic address:
Aims: CAR-T cell therapy has attracted considerable attention in recent years owing to its well-known efficacy against haematopoietic malignancies. Nevertheless, this immunotherapy fails against solid tumours due to hostile conditions found in the tumour microenvironment. In this context, many relevant biochemical factors have been thoroughly studied, but crucial mechanical cues have been underestimated.
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