Sarco/endoplasmic reticulum Ca-ATPase (SERCA) is a membrane protein on the endoplasmic reticulum (ER) that transports Ca from the cytosol into the ER. As its function is associated with various biological phenomena, SERCA has been recognized as a promising druggable target. Here, we report the second-strongest SERCA-inhibitory compound known to date, which we isolated from the marine cyanobacterium and named iezoside (). The structure of iezoside () is fundamentally different from that of any other SERCA inhibitor, and its potency is the strongest among marine natural products ( 7.1 nM). In this article, we report our comprehensive analysis of iezoside (), which covers its isolation, structural characterization supported by density functional theory (DFT) calculations and statistical analysis, total synthesis, and clarification of the mode of action of its potent antiproliferative activity (IC 6.7 ± 0.4 nM against HeLa cells).
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http://dx.doi.org/10.1021/jacs.2c04459 | DOI Listing |
Benzo (a) pyrene produced by food during high-temperature process enters the body through ingestion, which causes food safety issues to the human body. In order to alleviate the harm of foodborne benzo (a) pyrene to human health, a strain that can degrade benzo (a) pyrene was screened from Kefir, a traditional fermented product in Xinjiang. Bacillus cereus M72-4 is a Gram-positive bacteria sourced from Xinjiang traditional fermented product Kefir, under Benzo(a)pyrene stress conditions, there was 69.
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January 2025
Institute of Natural Antioxidants and Anti-Inflammation, Dali University, Dali, Yunnan, China.
Oxidative damage, oxidative inflammation, and a range of downstream diseases represent significant threats to human health. The application of natural antioxidants and anti-inflammatory agents can help prevent and mitigate these associated diseases. In this study, we aimed to investigate the effectiveness of walnut green husk (WNGH) as an antioxidant and anti-inflammatory agent in an in vitro setting.
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January 2025
Department of Rheumatology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, P.R. China.
Introduction: Lupus nephritis (LN) is one of the most frequent and serious organic manifestations of systemic lupus erythematosus (SLE). Autophagy, a new form of programmed cell death, has been implicated in a variety of renal diseases, but the relationship between autophagy and LN remains unelucidated.
Methods: We analyzed differentially expressed genes (DEGs) in kidney tissues from 14 LN patients and 7 normal controls using the GSE112943 dataset.
Acta Bioeng Biomech
September 2024
Department of Biochemistry and Biotechnology, Medical University of Lublin, Lublin, Poland.
: The synthesis of fluoridated apatite consists of several stages, among which the heat treatment has a significant impact on the physical and chemical properties. The present study aims to elucidate the influence of two different sintering methods on fluoride-substituted apatite properties. : For this purpose, a two F-substituted apatites were produced by heat treatment in different ways called "rapid sintering" and "slow sintering".
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September 2024
PhD, Associate Professor and Researcher Sports Science Department, Vice-president of Faculty of Human Social Sciences University of Beira Interior, Covilhã, Portugal; Research Center in Sports, Health and Human Development, Covilhã, Portugal.
From a current perspective, it is understood that body posture is influenced by individual asymmetries, cultural context, habitual body patterns, etiological factors and psychosocial factors allocated to the individual. Clarifying the musculoskeletal cause that originated the postural alteration is considered the clinical challenge in the treatment of pain or discomfort. Recent studies have shown the influence of changes in body weight on the distribution of plantar pressure and foot pain, emphasizing the importance of understanding these relationships.
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