AI Article Synopsis
- GFAP (Glial fibrillary acidic protein) is a protein found in astrocytes and neural stem cells, important for understanding gliomas.
- Multiple splice variants of the GFAP gene have been identified, resulting in different isoforms like GFAPα and GFAPδ.
- The review will highlight the expression of GFAP isoforms and their significance in diseases, particularly diffuse gliomas.
Article Abstract
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the discovery of the protein 50 years ago, multiple alternative splice variants of the GFAP gene have been discovered, leading to different GFAP isoforms. In this review, we will describe GFAP isoform expression from gene to protein to network, taking the canonical isoforms GFAPα and the main alternative variant GFAPδ as the starting point. We will discuss the relevance of studying GFAP and its isoforms in disease, with a specific focus on diffuse gliomas.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185002 | PMC |
| http://dx.doi.org/10.1177/17590914221102065 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!