Background: Type-2 diabetes mellitus is a common metabolic disorder characterized by insulin resistance, a relative impairment in insulin secretion, and a certain degree of genetic predisposition. The rapid rise in the prevalence of diabetes mellitus around the world has assisted in the development of new pharmacologically active compounds. The current study was aimed to investigate and validate the anti-diabetic activity of wild-grown plant L.
Material And Methods: molecular docking AutoDock tools 4.2 and glucose uptake assay using yeast cells was performed to investigate the anti-diabetic property of plant . Further, mRNA-based gene ontology enrichment analysis was performed to predict the imitated ontology by the bio-actives from .
Results: The study results reveal that among the 9 active phytoconstituents docked against GLUT-2 protein, α-onocerin possessed the highest binding affinity of -10.23 kcal/mol with no predicted adverse effects and also complies with Lipinski's rule of five. Also, studies reflected in a 5 mM glucose solution, hydro-alcoholic extract of at different concentrations enhanced glucose uptake in yeast cells.
Conclusion: extract enhanced the glucose uptake in yeast cells which may be due to the presence of α-onocerin; possessed the better interaction. Also, no adverse effects were predicted for α-onocerin. Thus, it can be speculated that may possess anti-diabetic activity which may be due to α-onocerin and other related bioactives; needs to be further confirmed experimental studies.
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| http://dx.doi.org/10.1007/s40200-022-00988-3 | DOI Listing |
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