Allergy information is often documented in diverse sections of the electronic health record (EHR). Systematically reconciling allergy information across the EHR is critical to improve the accuracy and completeness of patients' allergy lists and ensure patient safety. In this retrospective cohort study, we examined the prevalence of incompleteness, inaccuracy, and redundancy of allergy information for patients with a clinical encounter at any Mass General Brigham facility between January 1, 2018 and December 31, 2018. We identified 4 key places in the EHR containing reconcilable allergy information: 1) allergy modules (including free text comments and duplicate allergen entries), 2) medication laboratory tests results, 3) oral medication allergy challenge tests, and 4) medication orders that have been discontinued due to adverse drug reactions (ADRs). Within our cohort, 718,315 (45.2% of the total 1,588,979) patients had an active allergy entry; of which, 266,275 (37.1%) patient's records indicated a need for reconciliation.
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http://dx.doi.org/10.3233/SHTI220044 | DOI Listing |
Medicine (Baltimore)
January 2025
Shanxi Provincial Integrated TCM and WM Hospital, Taiyuan, China.
Rationale: Local anesthesia is a widely used technique for emergency wound closure, with lidocaine among the most commonly employed local anesthetics. Allergic reactions to lidocaine are rare, with anaphylaxis being even more uncommon.
Patient Concerns And Diagnosis: This report describes a 72-year-old male patient who presented with a right foot injury and underwent wound suturing under lidocaine local anesthesia.
Blood
January 2025
Division of Immunology and Allergy, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Leukopoiesis is lethally arrested in mice lacking the master transcriptional regulator PU.1. Depending on the animal model, subtotal PU.
View Article and Find Full Text PDFPLoS Pathog
January 2025
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
SARS-CoV-2 continues to transmit and evolve in humans and animals. White-tailed deer (Odocoileus virginianus) have been previously identified as a zoonotic reservoir for SARS-CoV-2 with high rates of infection and probable spillback into humans. Here we report sampling 1,127 white-tailed deer (WTD) in Pennsylvania, and a genomic analysis of viral dynamics spanning 1,017 days between April 2021 and January 2024.
View Article and Find Full Text PDFSci Adv
January 2025
Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
S-Palmitoylation is a reversible post-translational modification involving saturated fatty acid palmitate-to-cysteine linkage in the protein, which guides many aspects of macrophage physiology in health and disease. However, the precise role and underlying mechanisms of palmitoylation in infection of macrophages remain elusive. Here, we found that infection induced the expression of zinc-finger DHHC domain-type palmitoyl-transferases (ZDHHCs), particularly ZDHHC2, in mouse macrophages.
View Article and Find Full Text PDFPLoS One
January 2025
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Altered neural signaling in fibromyalgia syndrome (FM) was investigated with functional magnetic resonance imaging (fMRI). We employed a novel fMRI network analysis method, Structural and Physiological Modeling (SAPM), which provides more detailed information than previous methods. The study involved brain fMRI data from participants with FM (N = 22) and a control group (HC, N = 18), acquired during a noxious stimulation paradigm.
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