Ten parameters extracted from six currently used parametrizations of the four-parameter logistic model, and one new proposal, were examined for their statistical behavior in nonlinear least-squares estimation in combination with ELISA and RIA data. Those which are adequately near-linear on the basis of the Lowry-Morton lambda statistic were identified and can be recommended for use in practice.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Development of measured hydrodynamic information-based flood early warning system for small streams.
Water Res
October 2024
Research Institute, HydroSEM Co., Ltd., Yongin 16976, Korea. Electronic address:
In general, small stream basins, characterized by narrow channels and steep slopes, face heightened vulnerability to climate change-induced flooding, posing challenges for evacuation procedures. With the increasing intensity of floods and typhoons in recent years, urgent measures are necessary to mitigate damage in such areas. This research endeavors to address these challenges by developing a novel small stream flood early warning system (SSFEWS) tailored to small streams and piloting its application.
View Article and Find Full Text PDFPrediction of Individual Disease Progression Including Parameter Uncertainty in Rare Neurodegenerative Diseases: The Example of Autosomal-Recessive Spastic Ataxia Charlevoix Saguenay (ARSACS).
AAPS J
April 2024
Université Paris Cité, IAME, Inserm, F-75018, Paris, France.
The aim of this study was to develop a model to predict individual subject disease trajectories including parameter uncertainty and accounting for missing data in rare neurological diseases, showcased by the ultra-rare disease Autosomal-Recessive Spastic Ataxia Charlevoix Saguenay (ARSACS). We modelled the change in SARA (Scale for Assessment and Rating of Ataxia) score versus Time Since Onset of symptoms using non-linear mixed effect models for a population of 173 patients with ARSACS included in the prospective real-world multicenter Autosomal Recessive Cerebellar Ataxia (ARCA) registry. We used the Multivariate Imputation Chained Equation (MICE) algorithm to impute missing covariates, and a covariate selection procedure with a pooled p-value to account for the multiply imputed data sets.
View Article and Find Full Text PDFUltrasensitive cortisol electrochemical immunosensor amplifying by Au single-atom nanozymes and HRP enzymes.
Anal Chim Acta
May 2024
School of Pharmacy, Lanzhou University, State Key Laboratory of Applied Organic Chemistry, Codonopsis Radix Industrial Technology Engineering Research Center, Gansu Province, Lanzhou, Gansu, 730000, China. Electronic address:
Cortisol, a corticosteroid hormone as a primary stress hormone response to internal and external stress, has been regarded as a gold standard reliable biomarker to evaluate human mental stress. The double enzymes strategy, using nanozyme and enzyme amplifying the electrochemical signal, has been widely used to improve the performance of electrochemical biosensors. An ultra-sensitive electrochemical cortisol sensor based on Au single-atom nanozymes had been fabricated through HRP labeled anti-cortisol antibody binding with Au by Au-S bond.
View Article and Find Full Text PDFA compact microfluidic laser-induced fluorescence immunoassay system using avalanche photodiode for rapid detection of alpha-fetoprotein.
Anal Sci
July 2024
College of Computer and Electronic Information, Guangxi University, 100 East University Road, Nanning, 530004, Guangxi, China.
Alpha-fetoprotein (AFP), commonly employed for early diagnosis of liver cancer, serves as a biomarker for cancer screening and diagnosis. Combining the high sensitivity and specificity of fluorescence immunoassay (FIA), developing a low-cost and efficient immunoassay system for AFP detection holds significant importance in disease diagnosis. In this work, we developed a miniaturized oblique laser-induced fluorescence (LIF) immunoassay system, coupled with a microfluidic PMMA/paper hybrid chip, for rapid detection of AFP.
View Article and Find Full Text PDFThe lupus anticoagulant titer is associated with elevated antiphosphatidylserine/prothrombin immunoglobulin-M isotype antibody levels.
Int J Lab Hematol
August 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Background: Clot based assays used for lupus anticoagulant (LAC) detection are typically interpreted in a qualitative fashion and may not reflect LAC potency. In this cross-sectional study, we describe a method for quantifying the LAC titer using serial (dependent) two-fold dilutions in normal pooled plasma.
Methods: Serial dilutions of 51 residual plasma samples from 50 patients were tested using the Russell's viper venom screening time (DRVVT) and activated partial thromboplastin screening time (APTT) methodologies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!