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| http://dx.doi.org/10.26508/lsa.202201537 | DOI Listing |
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The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system.
Glia
February 2025
Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland.
Ubiquitination is a major post-translational regulatory mechanism that tunes numerous aspects of ubiquitinated target proteins, including localization, stability, and function. During differentiation and myelination, Oligodendrocytes (OLs) in the central nervous system and Schwann cells (SCs) in the peripheral nervous system undergo major cellular changes, including the tightly controlled production of large and accurate amounts of proteins and lipids. Such processes have been implied to depend on regulatory aspects of ubiquitination, with E3 ubiquitin ligases being generally involved in the selection of specific ubiquitination substrates by ligating ubiquitin to targets and granting target selectivity.
View Article and Find Full Text PDFSMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.
Autophagy
October 2024
Department of General Surgery, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, China.
The calcium-activated phosphatase PPP3/calcineurin dephosphorylates TFEB (transcription factor EB) to trigger its nuclear translocation and the activation of macroautophagic/autophagic targets. However, the detailed molecular mechanism regulating TFEB activation remains poorly understood. Here, we highlighted the importance of SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) in the activation of TFEB for lysosomal homeostasis.
View Article and Find Full Text PDFInvestigating Neuroplasticity Changes Reflected by BDNF Levels in Astrocyte-Derived Extracellular Vesicles in Patients with Depression.
Int J Nanomedicine
September 2024
Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Article Synopsis
- The study explores the neuroplasticity hypothesis in depression by measuring BDNF levels in astrocyte-derived extracellular vesicles from patients with major depressive disorder (MDD) and healthy controls.
- Results show that MDD patients have higher levels of CD81 and lower levels of BDNF in their ADEVs compared to controls, with improvements noted after SSRIs treatment.
- The findings suggest that ADEVs might be more reliable biomarkers for depression than conventional plasma markers, highlighting their potential in understanding and diagnosing the condition.
Background: The Endosomal Sorting Complex Required for Transport (ESCRT) is a highly conserved cellular machinery essential for many cellular functions, including transmembrane protein sorting, endosomal trafficking, and membrane scission. CHMP4B is a key component of ESCRT-III subcomplex and has been thoroughly studied in the meroistic ovaries of Drosophila melanogaster showing its relevance in maintaining this reproductive organ during the life of the fly. However, the role of the CHMP4B in the most basal panoistic ovaries remains elusive.
View Article and Find Full Text PDFPotentially functional variants of CHMP4A and PANX1 in the pyroptosis-related pathway predict survival of patients with non-oropharyngeal head and neck squamous cell carcinoma.
Mol Carcinog
September 2024
Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.
Background: Pyroptosis has been implicated in the advancement of various cancers. Triggering pyroptosis within tumors amplifies the immune response, thereby fostering an antitumor immune environment. Nonetheless, few published studies have evaluated associations between functional variants in the pyroptosis-related genes and clinical outcomes of patients with non-oropharyngeal head and neck squamous cell carcinoma (NON-ORO HNSCC).
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