AI Article Synopsis
- Encephalitis symptoms usually include seizures, memory issues, and altered consciousness, with initial cases sometimes involving psychosis, prompting questions about the relationship between first-episode psychosis (FEP) and encephalitis.
- Researchers studied 36 encephalitis patients with FEP, evaluating outcomes based on various factors, with a focus on the modified Rankin scale for measuring functional outcomes.
- Findings revealed that female sex and the need for mechanical ventilation during early treatment are significant indicators of worse outcomes, particularly highlighting mechanical ventilation as a strong prognostic factor for adverse developments in patients with encephalitis and FEP.
Article Abstract
Introduction: Although symptomatic manifestations in encephalitis vary, they typically include seizures, memory deficit(s), and altered consciousness. Psychosis also occurs as an initial manifestation. In clinical practice, clinicians often encounter the question of whether first-episode psychosis (FEP) originates from encephalitis itself or if encephalitis presenting with FEP develops concurrently. The prognosis of FEP among patients with overall encephalitis, including autoimmune encephalitis, remains uncertain.
Methods: We examined a prognostic factor in patients with encephalitis who had both FEP and CSF pleocytosis. A total of 36 patients who presented with FEP were enrolled. A score of ≥3 and ≤2 on the modified Rankin scale were defined as poor and good outcomes, respectively. A total of 13 independent variables were analyzed by the multivariate logistic regression analysis.
Results: Significant variables on univariate logistic regression analysis included female sex (OR 5.571, 95% CI: 1.297-23.934; p = 0.021) and the use of mechanical ventilation during the acute stage (OR 7.286, 95% CI: 1.508-35.211; p = 0.013). On multivariate logistic regression analysis, the use of mechanical ventilation during the acute stage (OR 5.446, 95% CI: 1.044-28.615; p = 0.044) was significantly associated with poor outcomes.
Conclusions: The use of mechanical ventilation is a poor prognostic factor of subacute encephalitis with FEP, and female sex may be a risk factor for unfavorable development of the disease.
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| http://dx.doi.org/10.1159/000524975 | DOI Listing |
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