AI Article Synopsis
- Researchers found that nearly 29% of older adults in India experience depression, with a noted association between depression and multiple chronic diseases, known as multimorbidity.
- The study utilized data from over 31,400 participants aged 60 and above, analyzing various health factors and using statistical methods to determine the relationship between multimorbidity and depression.
- Findings indicated that functional health factors, particularly among older women, play a significant mediating role in this relationship, emphasizing the necessity for improved chronic disease management and further research to understand the connections better.
Article Abstract
Researchers have long been concerned about the association between depression and the prevalence of multiple chronic diseases or multimorbidity in older persons. However, the underlying pathway or mechanism in the multimorbidity-depression relationship is still unknown. Data were extracted from a baseline survey of the Longitudinal Ageing Survey of India (LASI) conducted during 2017-18 (N = 31,464; aged ≥ 60 years). Depression was assessed using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). Multivariable logistic regression was used to examine the association. The Karlson-Holm-Breen (KHB) method was adopted for mediation analysis. The prevalence of depression among older adults was nearly 29% (men: 26% and women 31%). Unadjusted and adjusted estimates in binary logistic regression models suggested an association between multimorbidity and depression (UOR = 1.28; 95% CIs 1.27-1.44 and AOR = 1.12; 95% CIs 1.12-1.45). The association was particularly slightly strong in the older men. In addition, the association was mediated by functional health such as Self Rated Health (SRH) (proportion mediated: 40%), poor sleep (35.15%), IADL disability (22.65%), ADL disability (21.49%), pain (7.92%) and by behavioral health such as physical inactivity (2.28%). However, the mediating proportion was higher among older women as compared to older men. Physical inactivity was not found to be significant mediator for older women. The findings of this population-based study revealed that older people with multimorbidity are more likely to suffer depressive symptoms in older ages, suggesting the need for more chronic disease management and research. Multimorbidity and depression may be mediated by certain functional health factors, especially in older women. Further longitudinal research is needed to better understand the underlying mechanisms of this association so that future preventive initiatives may be properly guided.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173646 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269646 | PLOS |
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