AI Article Synopsis
- Research has focused on how the methylation of the MGMT gene affects the effectiveness of the drug temozolomide in treating glioblastoma, but there is less understanding of how MGMT's biochemical role relates to the development of glial tumors.
- MGMT is implicated in cancer risks linked to various environmental exposures, such as radiation and certain chemicals, which are also associated with brain tumor development, but studies on these interactions are lacking.
- Future studies on MGMT sequencing could help identify at-risk populations in specific industries, potentially leading to strategies for preventing gliomas and improving cancer treatment outcomes.
Article Abstract
Many investigations exist regarding the effect of the DNA repair enzyme MGMT (O 6 -methylguanine- DNA-methyltransferase)-encoding gene methylation on the antineoplasticity of temozolomide in glioblastoma patients. However, there exist surprisingly lesser studies regarding the associations between MGMT enzyme biochemistry with glial carcinogenesis. MGMT involves in risk of malignancies associated with ionizing radiation, smoking, exposure to polycyclic aromatic hydrocarbons, chlorinated solvents, vinylchloride and hairdyes. All these factors are also proposed to link with gliomagenesis, yet MGMT interactions with these carcinogens in gliomagenesis are not studied yet. In future, MGMT sequencing may be employed in vulnerable populations working in industries associated with exposure to these carcinogens to develop preventive strategies. Given that MGMT is involved in DNA repair, a polymorphism may simultaneously modify the risk of gliomas while enhancing temozolomide cytotoxicity in both marrow and tumor cells.
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| http://dx.doi.org/10.1097/CEJ.0000000000000746 | DOI Listing |
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