Three voratin compounds (-) were isolated from the symbiotic marine dinoflagellate . The planar structures of - were determined by 1D and 2D NMR spectroscopy and HRESIMS, and the relative and absolute configurations were established using ROESY correlations, Mosher's method, and quantum calculations. All of the compounds are zwitterionic and contain a dihydroindolizinium ring and a spiroketal moiety. Compounds - were found to exhibit therapeutic effects against benign prostatic hyperplasia (BPH), as evaluated using testosterone propionate-treated LNCap and RWPE-1 human prostate cells. This excellent activity suggests that - are promising for the development of BPH treatments.
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http://dx.doi.org/10.1021/acs.jnatprod.1c01190 | DOI Listing |
Mar Pollut Bull
January 2025
CSIR-National Institute of Oceanography, Dona Paula, Goa 403004, India.
Coastal deoxygenation impacts phytoplankton communities crucial for marine productivity. The inter- and intra-annual variability in phytoplankton communities at a shallow (27 m) station over the Western Indian Shelf (CaTS site, off Goa) during deoxygenation events of the late southwest monsoon (LSWM September-October) were studied from 2020 to 2023. The water column (0-27 m depth) experienced seasonal hypoxia/anoxia at subsurface depths (0-1.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
College of Life Science and Technology, and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Jinan University, Guangzhou 510362, China. Electronic address:
Harmful algal blooms (HABs), exacerbated by climate change and environmental disturbances, pose global challenges due to marine toxin contamination, particularly diarrhetic shellfish toxins (DSTs). DSTs are prevalent marine toxins, and understanding their synthesis is vital for managing fisheries and mitigating environmental triggers. This study delves into the synthesis mechanisms of DSTs in Prorocentrum arenarium and Prorocentrum lima, which vary in toxin types and concentrations.
View Article and Find Full Text PDFMar Biotechnol (NY)
January 2025
College of Earth, Ocean and Environment, School of Marine Science and Policy, University of Delaware, Lewes, DE, 19958, USA.
Application of algicides produced by naturally occurring bacteria is considered an environmentally friendly approach to control harmful algal blooms. However, few studies assess the effects of bacterial algicides on non-target species, either independently or with other stressors. Here, we measured sub-lethal effects of dinoflagellate-specific algicide IRI-160AA on the estuarine fish Fundulus heteroclitus and Menidia menidia in laboratory experiments.
View Article and Find Full Text PDFEnviron Monit Assess
January 2025
Chemical Oceanographic Division, CSIR-National Institute of Oceanography, Panaji, Goa, 403004, India.
In the present study, we investigated the dinoflagellate assemblages in the upper water column (< 150-m depth), focusing on the suboxic waters of the eastern Arabian Sea (EAS) along 68°E from 8°N to 21°N during the southwest monsoon 2020 (SWM-2020). Dinoflagellate abundance was higher in the upper water column (0-80-m depth, mean ± SD = 411 ± 903 cells L) compared to deeper waters (80-150-m depth, mean ± SD = 128 ± 216 cells L). Among 11 identified taxonomic dinoflagellate orders, Peridinales were predominant in the upper waters column (71%, mean ± SD = 285 ± 858 cells L).
View Article and Find Full Text PDFSci Total Environ
January 2025
Department of Marine Sciences, Berhampur University, Bhanja Bihar 760007, India.
The Indian coast has been experiencing an increase in algal bloom events over the decades. Owing to the regional and seasonal dynamics of algal biomass (proxy: chlorophyll-a, hereafter chl-a), a multitude of thresholds of chl-a has been defined for different parts of the global seas to determine algal bloom conditions. However, no such clear definition is given for the Indian coastal waters.
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