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Anopheles mosquitoes in Morocco: implication for public health and underlined challenges for malaria re-establishment prevention under current and future climate conditions.
Pest Manag Sci
April 2024
Laboratoire de Lutte contre les Maladies Infectieuses, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Background: The potential reappearance and/or expansion of vector-borne diseases is one of the terrifying issues awaiting humanity in the context of climate change. The presence of competent Anopheles vectors, as well as suitable environmental circumstances, may result in the re-emergence of autochthonous Malaria, after years of absence. In Morocco, international travel and migration movements from Malaria-endemic areas have recently increased the number of imported cases, raising awareness of Malaria's possible reintroduction.
View Article and Find Full Text PDFMalaria Diagnosis in Non-Endemic Settings: The European Experience in the Last 22 Years.
Microorganisms
October 2021
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy.
Accurate, prompt, and reliable tools for the diagnosis of malaria are crucial for tracking the successes or drawbacks of control and elimination efforts, and for future programs aimed at global malaria eradication. Although microscopy remains the gold standard method, the number of imported malaria cases and the risk of reappearance of autochthonous cases stimulated several laboratories located in European countries to evaluate methods and algorithms suited to non-endemic settings, where skilled microscopists are not always available. In this review, an overview of the field evaluation and a comparison of the methods used for the diagnosis of malaria by European laboratories is reported, showing that the development of numerous innovations is continuous.
View Article and Find Full Text PDFImported malaria in northern Italy: epidemiology and clinical features observed over 18 years in the Teaching Hospital of Brescia.
J Travel Med
January 2018
University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.
Background: Even though malaria incidence is decreasing worldwide, travel-related cases reported in Europe have remained stable in recent years. In Italy, incidence had increased in the 1990s, reaching a peak in 1999; a slow decline was then reported over the subsequent decade. To our knowledge, few published data are available on imported malaria in Italy since 2010.
View Article and Find Full Text PDFMyeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.
Cancer Res
April 2017
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Acquired resistance to BRAF inhibitors (BRAFi) in melanoma remains a common clinical obstacle, as is the case for any targeted drug therapy that can be developed given the plastic nature of cancers. Although there has been significant focus on the cancer cell-intrinsic properties of BRAFi resistance, the impact of BRAFi resistance on host immunity has not been explored. Here we provide preclinical evidence that resistance to BRAFi in an autochthonous mouse model of melanoma is associated with restoration of myeloid-derived suppressor cells (MDSC) in the tumor microenvironment, initially reduced by BRAFi treatment.
View Article and Find Full Text PDFFeeding horses with industrially manufactured pellets with fungal spores to promote nematode integrated control.
Vet Parasitol
October 2016
Equine Diseases Study Group (COPAR, GI-2120), Animal Pathology Department, Veterinary Faculty, Santiago de Compostela University, 27002-Lugo Spain. Electronic address:
The usefulness of pellets industrially manufactured with spores of parasiticide fungi as a contribution to integrated nematode control was assessed in grazing horses throughout sixteen months. Two groups of 7 Pura Raza Galega autochthonous horses (G-T and G-P) were dewormed pour-on (1mg Ivermectin/kg bw) at the beginning of the trial, and other group (G-C) remained untreated. The G-P was provided daily with commercial pellets to which was added a mixture of fungal spores during the industrial manufacturing (2×10 spores of Mucor circinelloides and same dose of Duddingtonia flagrans/kg), and G-T and G-C received pellets without spores.
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