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A new study employs CRISPR/Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability for H3K27ac in transcriptional activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586490 | PMC |
| http://dx.doi.org/10.1038/s41588-022-01096-x | DOI Listing |
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