Microsporidia: a new taxonomic, evolutionary, and ecological synthesis.

Trends Parasitol

International Centre of Excellence for Aquatic Animal Health, Centre for Environment, Fisheries, and Aquaculture Science, Barrack Road, The Nothe, Weymouth DT4 8UB, UK; Biosciences, University of Exeter, Stocker Road, Exeter, EX4 4HB, UK; Department of Life Sciences, The Natural History Museum, Cromwell Road, London, SW7 5BD, UK.

Published: August 2022

Microsporidian diversity is vast. There is a renewed drive to understand how microsporidian pathological, genomic, and ecological traits relate to their phylogeny. We comprehensively sample and phylogenetically analyse 125 microsporidian genera for which sequence data are available. Comparing these results with existing phylogenomic analyses, we suggest an updated taxonomic framework to replace the inconsistent clade numbering system, using informal taxonomic names: Glugeida (previously clades 5/3), Nosematida (4a), Enterocytozoonida (4b), Amblyosporida (3/5), Neopereziida (1), and Ovavesiculida (2). Cellular, parasitological, and ecological traits for 281 well-defined species are compared with identify clade-specific patterns across long-branch Microsporidia. We suggest that future taxonomic circumscriptions of Microsporidia should involve additional markers (SSU/ITS/LSU), and that a comprehensive suite of phenotypic and ecological traits help to predict broad microsporidian functional and lineage diversity.

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http://dx.doi.org/10.1016/j.pt.2022.05.007DOI Listing

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