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A Potential Use of Vidarabine: Alleviation of Functional Constipation Through Modulation of the Adenosine A2A Receptor-MLC Signaling Pathway and the Gut Microbiota.
Int J Mol Sci
November 2024
Division of Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Vidarabine (VID) is an antiviral medication that is commonly utilized to treat conditions such as hand, foot, and mouth disease and herpes. Constipation is a prevalent complication of these diseases. Could VID treat these diseases by influencing defecation behavior? To date, no studies have been conducted on the potential of VID to relieve constipation.
View Article and Find Full Text PDFResearch progress and application prospects of animal models of group B Coxsackievirus infections.
Emerg Microbes Infect
December 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People's Republic of China.
Group B Coxsackieviruses (CVBs) consist of six serotypes, CVB1 to CVB6, which can clinically affect the heart, brain, liver, pancreas and other organs, causing myocarditis, encephalitis, myelitis, pancreatitis, hand-foot-and-mouth disease (HFMD) and other diseases, and can even lead to death. CVBs are widespread globally and highly contagious. However, there are currently no approved CVB vaccines or effective treatments.
View Article and Find Full Text PDFKnowledge, attitudes, and practices status among caregivers of infants and toddlers towards hand, foot and mouth disease: a cross-sectional study.
BMC Public Health
November 2024
School of Public Health, Southern Medical University, Guangzhou, China.
Article Synopsis
- Hand, foot and mouth disease (HFMD) is a common illness in kids, and this study looks at how well caregivers in Guangzhou understand it, focusing on their knowledge, attitudes, and practices (KAP).
- The study involved interviews with 1,094 caregivers, revealing that many had low concern for isolation measures and recurrent infections despite some good knowledge and practices about HFMD.
- Findings suggest that factors like caregiver identity, education, and household size affect KAP levels, highlighting the need for better health education for those caring for young children.
Impact of non-pharmacological interventions on incidence of hand, foot and mouth disease during the COVID-19 pandemic: a large population-based observational study.
BMC Infect Dis
November 2024
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, China.
Background: Hand, foot, and mouth disease (HFMD) is a highly prevalent and contagious disease, particularly in children under five years old. Its transmission route resembles that of COVID-19. During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) were implemented to curb viral spread, which may have concurrently reduced HFMD incidence.
View Article and Find Full Text PDF[Relationship between ripretinib concentration and the prognosis of advanced gastrointestinal stromal tumors in China: a multicenter study].
Zhonghua Wei Chang Wai Ke Za Zhi
November 2024
Department of Gastric Surgery, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial Hospital), Nanjing210029, China.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of ripretinib for patients with advanced gastrointestinal mesenchymal stromal tumors (GISTs), focusing on how blood levels of the drug relate to patient outcomes.
- Researchers conducted a retrospective analysis involving 79 patients treated at various hospitals, ensuring that they met specific criteria regarding medication administration.
- The study used sophisticated statistical methods to assess adverse reactions, treatment efficiency, and the impact of drug concentration on patient survival rates, finding average blood concentrations of ripretinib for the group.
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