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University of Navarra, ISTUN Institute of Tropical Health, School of Pharmacy and Nutrition, Department of Pharmaceutical Technology and Chemistry, Campus Universitario, Irunlarrea 1, Pamplona 31008, Spain. Electronic address:
Published: September 2022
AI Article Synopsis
* Research indicates that sulfur-containing compounds may effectively combat the Trypanosoma cruzi parasite, and substituting sulfur with selenium may enhance their effectiveness.
* The study evaluates various selenium compounds against their sulfur equivalents to propose new drug candidates for treating Chagas disease, while highlighting the need for further research to confirm their efficacy.
Article Abstract
Current treatment for Chagas disease is based on only two drugs: benznidazole and nifurtimox. Compounds containing sulfur (S) in their structure have shown promising results in vitro and in vivo against Trypanosoma cruzi, the parasite causing Chagas disease. Notably, some reports show that the isosteric replacement of S by selenium (Se) could be an interesting strategy for the development of new compounds for the treatment of Chagas disease. To date, the activity against T. cruzi of three Se- containing groups has been compared with their S counterparts: selenosemicarbazones, selenoquinones, and selenocyanates. More studies are needed to confirm the positive results of Se compounds. Therefore, we have investigated S compounds described in the literature tested against T. cruzi. We focused on those tested in vivo that allowed isosteric replacement to propose their Se counterparts as promising compounds for the future development of new drugs against Chagas disease.
