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Development of translationally active cell lysates from different filamentous fungi for application in cell-free protein synthesis.
Enzyme Microb Technol
January 2025
Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Universitätsplatz 1, Senftenberg 01968, Germany. Electronic address:
There is an enormous potential for cell-free protein synthesis (CFPS) systems based on filamentous fungi in view of their simple, fast and mostly inexpensive cultivation with high biomass space-time yields and in view of their catalytic capacity. In 12 of the 22 different filamentous fungi examined, in vitro translation of at least one of the two reporter proteins GFP and firefly luciferase was detected. The lysates showing translation of a reporter protein usually were able to synthesize a functional cell-free expressed unspecific peroxygenase (UPO) from the basidiomycete Cyclocybe (Agrocybe) aegerita.
View Article and Find Full Text PDFSimulation of fluid flow with Cuprophan and AN69ST membranes in the dialyzer during hemodialysis.
Biomed Phys Eng Express
January 2025
Ingeniería y Tecnología, Universidad Nacional Autonoma de Mexico Facultad de Estudios Superiores Cuautitlan, Av. 1o de Mayo S/N, Santa María las Torres, Campo Uno, 54740 Cuautitlán Izcalli, Edo. de Méx., Cuautitlan Izcalli, Estado de México, 54740, MEXICO.
Hemodialysis is a crucial procedure for removing toxins and waste from the body when kidneys fail to perform this function effectively. This study addresses the need to improve the efficiency and biocompatibility of membranes used in dialyzers. We simulate fluid flow through two types of membranes, Cuprophan (cellulosic) and AN69ST (synthetic), to understand the complex mechanisms involved and quantify key variables such as pressure, concentration, and flow.
View Article and Find Full Text PDFFull fine-tuning strategy for endoscopic foundation models with expanded learnable offset parameters.
Biomed Phys Eng Express
January 2025
Shandong Normal University, Jinan, Jinan, Shandong, 250014, CHINA.
In the medical field, endoscopic video analysis is crucial for disease diagnosis and minimally invasive surgery. The Endoscopic Foundation Models (Endo- FM) utilize large-scale self-supervised pre-training on endoscopic video data and leverage video transformer models to capture long-range spatiotemporal dependencies. However, detecting complex lesions such as gastrointestinal metaplasia (GIM) in endoscopic videos remains challenging due to unclear boundaries and indistinct features, and Endo-FM has not demonstrated good performance.
View Article and Find Full Text PDFEvaluating oomycete pathogen and community responses to chemical- and Slow Sand Filtration-based water treatment strategies to enable water recycling in nursery production systems.
Plant Dis
January 2025
University of California Davis, Plant Pathology, 1 Shields Ave, Davis, California, United States, 95616;
While recycling irrigation water can reduce water use constraints and costs in nurseries, adoption is hindered by the associated risk of recirculating and spreading waterborne pathogens. To enable regional water re-use, this study assessed oomycete re-circulation risks and recycled water treatment efficacy at organismal and community scales. In culture-based analysis of recycled pond water at two Mid-Atlantic nurseries across three years, diverse oomycetes (12+ species) were detected using culture-based analysis, with Phytopythium helicoides as the dominant species; MiSeq analysis detected eight of these species, plus 24 additional taxa.
View Article and Find Full Text PDFInvestigation on the Heating Effects of Intra-Tumoral Injectable Magnetic hydrogels (IT-MG) for Cancer Hyperthermia.
Biomed Phys Eng Express
January 2025
Biomedical Engineering , University of Wisconsin-Milwaukee College of Engineering and Applied Science, 3203 N Downer Ave, Milwaukee, Milwaukee, Wisconsin, 53211-3029, UNITED STATES.
Capacitive-based radiofrequency (Rf) radiation at 27 MHz offers a non-invasive approach for inducing hyperthermia, making it a promising technique for thermal cancer therapy applications. To achieve focused and site-specific hyperthermia, external material is required that efficiently convert Rf radiation into localized heat. Nanomaterials capable of absorbing Rf energy and convert into heat for targeted ablation are of critical importance.
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