In the present study, health services networks were classified into low-level hospitals (provision of public health services) and high-level hospitals (providing specialized health services), which are at risk of being disrupted. They refer the patients to high-level hospitals for inpatient visits or emergencies by ambulance. In the present case, patients are divided into two categories: high priority (the category in which immediate service delivery is needed) and low priority. A stochastic robust dynamic mathematical model for location and allocation of health network regarding limited capacity and disturbance is developed to reduce the total costs and include the basic features of a real problem such as limited capacity. Regarding limited capacity for hospitals, the health network needs redefinition of different layers in the disturbance situation. In this study, we reduce the total costs by reducing hospital costs and costs such as transportation and service to patients. Two metaheuristic algorithms consisting of Non-dominated Sorting Genetic Algorithm II (NSGA-II) and Particle Swarm Optimization (PSO) have been applied to solve the model. Taguchi method design minimizes the cost of parameter tuning, including the level of factors related to the proposed. The results showed the method's applicability for large-scale problems that could evaluate different tools for decision-makers to select effective management strategies in constructing a dependable and robust healthcare network. For example, the total cost is minimized in conditions considered in the genetic algorithm, the population parameter at the highest level, 150, the intersection parameters, and the probability of mutation at the lowest level, 0.7 and 0.1.
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http://dx.doi.org/10.1016/j.compbiomed.2022.105649 | DOI Listing |
Chemosphere
December 2024
College of Land Science and Technology, China Agricultural University, Beijing 100193, PR China. Electronic address:
Heavy metals released from metallic sulfidic tailings pose significant environmental threats by contaminating surface and groundwater in mining areas. Sustainable rehabilitation methods are essential to remove or stabilize these metals, improving the quality of acid mine drainage and minimizing pollution. This study examines the adsorption capacity of zinc ions (Zn) by different iron-silicate mineral groups under natural weathering and bacteria-regulated weathered conditions.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center; Memphis, 38163. Electronic address:
Familial Alzheimer's disease (FAD) is frequently associated with mutations in the amyloid precursor protein (APP), which are thought to lead to cognitive deficits by impairing NMDA receptor (NMDAR)-dependent forms of synaptic plasticity. Given the reliance of synaptic plasticity on NMDAR-mediated Ca entry, shaping of NMDAR activity by APP and/or its disease-causing variants could provide a basis for understanding synaptic plasticity impairments associated with FAD. A region of APP (residues 639-644 within APP695) processed by the γ-secretase complex, which generates amyloid β (Aβ) peptides, is a hotspot for FAD mutations.
View Article and Find Full Text PDFNeural Netw
December 2024
School of Computer Science, Wuhan University, Luojiashan Road, Wuchang District., Wuhan, 430072, Hubei Province, China; Hubei Key Laboratory of Digital Finance Innovation, Hubei University of Economics, No. 8, Yangqiaohu Avenue, Zanglong Island Development Zone, Jiangxia District, Wuhan, 2007, Hubei Province, China. Electronic address:
The remarkable success of Graph Neural Networks underscores their formidable capacity to assimilate multimodal inputs, markedly enhancing performance across a broad spectrum of domains. In the context of molecular modeling, considerable efforts have been made to enrich molecular representations by integrating data from diverse aspects. Nevertheless, current methodologies frequently compartmentalize geometric and semantic components, resulting in a fragmented approach that impairs the holistic integration of molecular attributes.
View Article and Find Full Text PDFJ Chromatogr A
December 2024
College of Environmental Science and Engineering, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. Electronic address:
Here we covalently constructed abundant long-chain hydroxyl groups-functionalized magnetic microporous organic networks (MMON-2OH) for detection of eight Triazine herbicides (THs) in honey and water samples. MMON-2OH owned a high surface area (287.86 m²/g), enhanced water compatibility, and increased exposure of long-chain hydroxyl groups, which significantly improved enrichment capacity for THs.
View Article and Find Full Text PDFThromb Res
December 2024
School of Public Health, Physiotherapy & Sports Science, Health Sciences Building, University College Dublin, D04 V1W8, Ireland. Electronic address:
Background: Half of people post pulmonary embolism (PE) experience ongoing symptoms such as dyspnoea, anxiety and depression, exercise limitation and fatigue. These symptoms can reduce their quality of life (QoL), psychological wellbeing, and functional capacity. The efficacy of rehabilitation interventions to prevent and manage these symptoms has not been established.
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