Background And Objectives: One of the major causes of urinary tract infections is Currently, few studies investigated the mechanisms of resistance to colistin in Iran. The current study aimed to determine the prevalence of plasmid and chromosome-mediated resistance to colistin in isolates.
Materials And Methods: 177 urine samples were collected from patients with urinary tract infections hospitalized in the intensive care unit (ICU) of hospitals in the city of Qazvin. isolates were identified by standard biochemical methods, resistance to colistin among isolates were tested by disk diffusion and microbroth dilution methods. The chromosomal mutation and presence of the mcr genes in colistin-resistant were evaluated by PCR.
Results: Out of 177 samples, 65 were obtained from patients in the ICU. Six colistin-resistant isolates were isolated with MIC values ≥4 μg/mL, none of them was positive for . In 4 isolates, missense mutation in gene resulted in amino acid substitutions and in one isolate of gene was found intact gene.
Conclusion: The results suggest that mutation was the main mutation among colistin-resistant isolates and plasmid-borne colistin resistance was not expanded among strains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085550 | PMC |
| http://dx.doi.org/10.18502/ijm.v14i1.8798 | DOI Listing |
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