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3D hydrodynamic focusing in microscale channels formed with two photoresist layers. | LitMetric

3D hydrodynamic focusing in microscale channels formed with two photoresist layers.

Microfluid Nanofluidics

Electrical and Computer Engineering, Brigham Young University, 450 Engineering Building, Provo, UT 84602, USA.

Published: November 2019

AI Article Synopsis

Article Abstract

3D hydrodynamic focusing was implemented with channel cross-section dimensions smaller than 10 μm. Microchannels were formed using sacrificial etching of two photoresist layers on a silicon wafer. The photoresist forms a plus-shaped prismatic focusing fluid junction which was coated with plasma-enhanced chemical-vapor-deposited oxide. Buffer fluid carried to the focusing junction envelopes an intersecting sample fluid, resulting in 3D focusing of the sample stream. The design requires four fluid ports and operates across a wide range of fluid velocities through pressure-driven flow. The focusing design was integrated with optical waveguides to interrogate fluorescing particles and confirm 3D focusing. Particle diffusion away from a focused stream was characterized.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162057PMC
http://dx.doi.org/10.1007/s10404-019-2293-zDOI Listing

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