Hyperandrogenism and hyperinsulinemia have resulted from dysfunction of the theca cell of the ovary and adipose tissue and each one potentiates the other in patients with androgen excess disorders polycystic ovary disease and idiopathic hirsutism. Possible external and/or internal triggers can produce such cellular dysfunction. There is evidence that sodium valproate acts as a trigger of cellular dysfunction and produces both hyperinsulinemia and hyperandrogenism. Therefore, the elimination of these triggers can help the patients to recover from hyperinsulinemia, insulin resistance and hyperandrogenism.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134025 | PMC |
| http://dx.doi.org/10.4239/wjd.v13.i5.417 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reduced lipid and glucose oxidation and reduced lipid synthesis in AMPKα2 myotubes.
Arch Physiol Biochem
January 2025
Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Norway.
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) plays a crucial role in regulation of metabolic homeostasis. To understand the role of the catalytic α2 subunit of AMPK in skeletal muscle energy metabolism, myotube cultures were established from and mice. Myotubes from mice had lower basal oleic acid and glucose oxidation compared to myotubes from mice.
View Article and Find Full Text PDFThe influence of preoperative fat distribution on post-bariatric surgery body mass index and body weight loss.
Diabetes Obes Metab
January 2025
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Background: The body weight following bariatric surgery is a primary concern for both healthcare professionals and surgical candidates. However, it remains unclear whether variations in preoperative fat distribution influence weight loss outcomes.
Objective: The aim of this study was to evaluate the effect of abdominal fat distribution on postoperative weight loss and body mass index (BMI) reduction, and to clarify the role of different fat depots in weight loss outcomes.
Change in adiposity indices after 1 year of peritoneal dialysis: a single-center cohort study.
Clin Kidney J
January 2025
Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China.
Background: Weight gain is common after starting peritoneal dialysis (PD). Several adiposity indices have been developed recently as potential indicators of visceral adiposity and lipid accumulation. We aim to investigate the prevalence and prognostic implications of the change in adiposity indices after 1 year of PD.
View Article and Find Full Text PDFSpinal tissue identification using a Forward-oriented endoscopic ultrasound technique.
Biomed Eng Lett
January 2025
School of Information Science and Technology, ShanghaiTech University, No. 393 Middle Huaxia Road, Pudong New District, Shanghai, 201210 China.
The limited imaging depth of optical endoscope restrains the identification of tissues under surface during the minimally invasive spine surgery (MISS), thus increasing the risk of critical tissue damage. This study is proposed to improve the accuracy and effectiveness of automatic spinal soft tissue identification using a forward-oriented ultrasound endoscopic system. Total 758 ex-vivo soft tissue samples were collected from ovine spines to create a dataset with four categories including spinal cord, nucleus pulposus, adipose tissue, and nerve root.
View Article and Find Full Text PDFAstrocyte Loss Augments Body Weight Through Reduction in Adipose Sympathetic Outflows.
Glia
January 2025
Department of Medicine Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York, USA.
Emerging evidence indicates that astrocytes modulate energy metabolism and homeostasis. However, one important but poorly understood element is the necessity of astrocytes in the control of body weight. Here, we apply viral vector-assisted brain-region selective loss of astrocytes to define physiological roles played by astrocytes in the arcuate nucleus of the hypothalamus (ARH) and to elucidate the involved mechanism.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!