AI Article Synopsis
- This study reviews the global collaboration in research on mesenchymal stem cells (MSCs) related to liver diseases using bibliometrics to assess trends and knowledge structures from 2001-2021.
- A total of 3,404 publications were analyzed, showing an increase in MSC research, primarily from institutions in China and the USA, with Li L being the most prolific author.
- Key emerging topics identified include liver scaffolds, MSC therapy, and keywords like "machine perfusion" and "microRNAs," providing insights for future research directions.
Article Abstract
Background: Mesenchymal stem cells (MSCs) have important research value and broad application prospects in liver diseases. This study aims to comprehensively review the cooperation and influence of countries, institutions, authors, and journals in the field of MSCs in liver diseases from the perspective of bibliometrics, evaluate the clustering evolution of knowledge structure, and discover hot trends and emerging topics.
Methods: The articles and reviews related to MSCs in liver diseases were retrieved from the Web of Science Core Collection using Topic Search. A bibliometric study was performed using CiteSpace and VOSviewer.
Results: A total of 3404 articles and reviews were included over the period 2001-2021. The number of articles regarding MSCs in liver diseases showed an increasing trend. These publications mainly come from 3251 institutions in 113 countries led by China and the USA. Li L published the most papers among the publications, while Pittenger MF had the most co-citations. Analysis of the most productive journals shows that most are specialized in medical research, experimental medicine and cell biology, and cell & tissue engineering. The macroscopical sketch and micro-representation of the whole knowledge field are realized through co-citation analysis. Liver scaffold, MSC therapy, extracellular vesicle, and others are current and developing areas of the study. The keywords "machine perfusion", "liver transplantation", and "microRNAs" also may be the focus of new trends and future research.
Conclusions: In this study, bibliometrics and visual methods were used to review the research of MSCs in liver diseases comprehensively. This paper will help scholars better understand the dynamic evolution of the application of MSCs in liver diseases and point out the direction for future research.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160197 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.859972 | DOI Listing |
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