The understanding of the genesis of life-threatening cancer and its invasion calls for urgent development of novel technologies for real-time observations, early diagnosis, and treatment. Quantum dots (QDs) grabbed the spotlight in oncology owing to their excellent photostability, bright fluorescence, high biocompatibility, good electrical and chemical stability with minimum invasiveness. Recently, carbon QDs (CQDs) have become popular over toxic inorganic QDs in the area of bioimaging, biosensing, and drug delivery. Further, CQDs derived from natural sources like biomolecules and medicinal plants have drawn attention because of their one-pot, low-cost and ease of synthesis, along with remarkable tunable optical properties and biocompatibility. This review introduces the synthesis and properties of CQDs derived from natural sources, focusing on the applicability of CQD-based technologies as nano-theranostics for the diagnosis and treatment of cancer. Furthermore, the current issues and future directions for the transformation of CQDs-based nanotechnologies to clinical applications are highlighted.
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http://dx.doi.org/10.3389/fbioe.2022.882100 | DOI Listing |
Nano Lett
January 2025
State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yu Tian Road, Shanghai 200083, China.
Enhancing photoluminescence (PL) efficiency in colloidal quantum dots is pivotal for next-generation near-infrared photodetectors, imaging systems, and photonic devices. Conventional methods, especially metal-based plasmonic structures, suffer from large optical losses, which limits their practical use. Here, we introduce a quasi-bound state in the continuum (quasi-BIC) metasurface on a silicon-on-insulator platform, tailored to provide high-quality factor resonances with minimized losses.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
The tunability of the energy bandgap in the near-infrared (NIR) range uniquely positions colloidal lead sulfide (PbS) quantum dots (QDs) as a versatile material to enhance the performance of existing perovskite and silicon solar cells in tandem architectures. The desired narrow bandgap (NBG) PbS QDs exhibit polar (111) and nonpolar (100) terminal facets, making effective surface passivation through ligand engineering highly challenging. Despite recent breakthroughs in surface ligand engineering, NBG PbS QDs suffer from uncontrolled agglomeration in solid films, leading to increased energy disorder and trap formation.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
In this study, we present an intelligent electromagnetic-actuated microfluidic chip integrated with a G-quadruplex DNAzyme-based biocatalysis platform for rapid and sensitive tetracycline (TC) detection. In this sensing system, TC significantly quenches fluorescent magnetic carbon dots (M-CDs) via the internal filtration effect and dynamic quenching (the excitation and emission wavelength at 350 and 440 nm, respectively). Then, the G-quadruplex on the M-CDs-Aptamer is exposed and bound with hemin to form hemin-G-quadruplex DNAzyme, catalyzing the conversion of 3,3',5,5'-tetramethylbenzidine to produce blue color.
View Article and Find Full Text PDFBiotechnol Rep (Amst)
March 2025
Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK.
Unlabelled: Ongoing research in biosensor technologies has led to advanced functional materials for healthcare diagnostics, and bacteriophages (phages), demonstrating exceptional utility due to their high specificity, accuracy, rapid, label-free, and wireless detection capabilities with minimal false-positive results. Phage-based-pathogen-detecting biosensors (PBPDBs) include surface plasmon resonance (SPR) biosensors, magnetoelastic (ME), electrochemical, and quartz crystal microbalance (QCM) biosensors. Commonly used substrates for PBPDBs are gold, silicon, glass, carbon-based materials, magnetic particles, and quantum dots.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Microbiology (Biocenter 1, Viikinkaari 9), Faculty of Agriculture and Forestry, University of Helsinki, Finland.
The white rot fungus was investigated for its ability to decolorize the reactive textile dye Reactive Black 5 (RB5) that was co-exposed to CdCl and quantum dots (QDs) consisting of a CdTe core capped with two different hydrophilic organic ligands (NAC and MPA). Without co-exposure, completely decolorizes RB5 within 9 days. The highest inhibitory effect was found for soluble CdCl with an EC of 583 μg l, followed by MPA-QDs (10,628 μg l) and NAC-QDs (17,575 μg l).
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