Angioedema is an edema of skin, mucosa, respiratory, and gastrointestinal tract, due to vascular permeability increase, resulting in plasma extravasation, which has been associated with multiple causes. We describe a case of a patient who was prescribed with enalapril and presented with symptoms suggestive of angioedema.
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Enalapril-induced angioedema: A forgotten adverse event.
Clin Case Rep
June 2022
Department of Dermatology Universidad de Buenos Aires Buenos Aires Argentina.
Angioedema is an edema of skin, mucosa, respiratory, and gastrointestinal tract, due to vascular permeability increase, resulting in plasma extravasation, which has been associated with multiple causes. We describe a case of a patient who was prescribed with enalapril and presented with symptoms suggestive of angioedema.
View Article and Find Full Text PDFEnalapril-Induced Angioedema: Two Case Reports in a Rural Health Facility in Kenya.
Cureus
May 2018
Department of Clinical Medicine, Nyakach County Hospital.
Tolerability, a good safety profile, affordability, and a preponderance to afford cardio-renal protection in patients with diabetes make enalapril one of the most commonly prescribed angiotensin-converting enzyme (ACE) inhibitors. However, there is low awareness of enalapril/ACE inhibitor-induced angioedema among medical personnel. This is because the diagnosis presents an ongoing challenge, particularly when the presentation is delayed following long-term therapy with ACE inhibitors.
View Article and Find Full Text PDFAn encounter with enalapril-induced resistant, life-threatening angioedema at rural health center in Botswana.
Indian J Crit Care Med
October 2016
Department of Anaesthesiology and Critical Care Medicine, Sekgoma Memorial Hospital, Government of Botswana, Serowe, Botswana, Africa.
Angioedema, a rare, potentially fatal and usually self-limiting adverse effect of therapy with enalapril, is always a challenging encounter for an intensive care specialist in a rural setup. Here, we present a 74-year-old female, who presented to the Emergency Department of Sekgoma Memorial Hospital, Serowe village, Botswana, with progressive swelling of her face, tongue and breathing difficulty just 2 days after starting tablet enalapril. She failed to respond to usual treatment with adrenaline, steroids, and H1-antihistaminic agent, but she responded well with intravenous fresh-frozen plasma infusion.
View Article and Find Full Text PDFEnalapril-induced angioedema: a dental concern.
Gen Dent
January 2012
Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, Lincoln, USA.
Drug-induced angioedema is a rare but potentially life-threatening side effect of increased levels of bradykinin. It may be overlooked and diagnosed as a dental-related problem due to its appearance as facial swelling. A clear understanding of the pathophysiology of angioedema can better serve both physicians and dentists in providing the most appropriate care for patients.
View Article and Find Full Text PDFLong-acting ACE inhibitor-induced angioedema.
Allergy Proc
June 1992
Division of Allergy and Immunology, UMDNJ-New Jersey Medical School, Newark 07103-2714.
Angioedema is a known adverse reaction of the angiotensin converting enzyme (ACE) inhibitors. Although current investigations are in progress, the exact pathogenesis of ACE inhibitor-induced angioedema is still unclear. Most cases of angioedema we have seen remitting from the short-acting ACE inhibitor, captopril, have presented with mild angioedema, controlled with antihistamines and glucocorticosteroids.
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