The C3-selective homodimerization of quinoxalinones is described. A C3-sp carbanion species generated through deprotonation of quinoxalinone using potassium -butoxide (KOBu) transfers an electron (single electron transfer mechanism) to a second quinoxalinone, affording a radical-anion intermediate. The radical scavenging and electron paramagnetic resonance (EPR) experiments support the plausible radical reaction pathway. A mild reaction temperature and a short reaction time were attained under cost-effective conditions, which reveal the amenability of this protocol to pharmaceutical and chemical industries.
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