AI Article Synopsis
- The inflammasome, particularly the NLRP3 type, is linked to the immune response and is found to be involved in noise-induced hearing loss (NIHL).
- Miniature pigs exposed to loud white noise (120 dB(A)) underwent auditory tests and various laboratory analyses to study the expression of inflammasome-related proteins.
- Results indicated increased levels of NLRP3 and other inflammatory markers in the cochlea post-exposure, suggesting the activation of NLRP3-inflammasomes could be a key factor in the development of NIHL.
Article Abstract
The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system. It plays a crucial role in the pathological process of noise-induced hearing loss (NIHL). However, the mechanisms of NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in NIHL have not been clearly demonstrated. In this study, miniature pigs were exposed to white noise at 120 dB(A) and auditory brainstem response measurements were used to measure their hearing function. Immunofluorescence staining, confocal laser scanning microscopy, western blot assay, and quantitative reverse transcription-polymerase chain reaction were used to analyze inflammasome-related protein distribution and expression. NLRP3, interleukin-1β, interleukin-18, and cleaved-caspase-1 were highly expressed in the cochlea after 120 dB(A) white noise exposure. Our findings suggest that NLRP3-inflammasomes in the cochlea may be activated after acoustic trauma, which may be an important mechanism of noise-induced hearing loss.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165387 | PMC |
| http://dx.doi.org/10.4103/1673-5374.339499 | DOI Listing |
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