Described here is the chromium-catalyzed cleavage of C(aryl)-SMe bonds leading to coupling with organomagnesium to give functionalized benzaldehydes under mild conditions. This reaction was promoted specifically by a low-cost and simple CrCl salt used as a precatalyst, enabling synchronous activations of -C(aryl)-SMe and '-C(aryl)-H bonds to achieve difunctionalization of benzaldimines. This work provided a strategy for accessing arylated, alkylated, and diarylated benzaldehyde derivatives as a result of the couplings of C(aryl)-SMe and C(aryl)-SMe/C(aryl)-H bonds promoted with cost-effective Cr catalysis.
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