Introduction: Growth discordancy in dichorionic diamniotic (DCDA) twin gestations is a known complication associated with adverse neonatal outcomes. We aimed to study the differences in placental pathology, in relation to fetal sex, in DCDA twin gestations complicated with growth discordancy.
Methods: The medical files of all DCDA twin deliveries complicated by growth discordancy between 2010 and 2020 were reviewed. Growth discordance was defined as a gap between twin birthweights > 20%. A comparison was made between female vs. male growth discordant twins. Placental lesions were classified as lesions related to maternal or fetal malperfusion lesions (MVM, FVM), vascular and villous changes, and inflammatory lesions.
Results: Included 174 DCDA twins. Eighty-eight were in the discordant female group and eighty-six in the discordant male group. The groups did not differ in maternal demographics, pregnancy characteristics, and neonatal outcome. The discordant male group had a higher rate of placental MVM lesions as compared to the discordant female group (p = 0.003). The increased rate of placental MVM lesions in the discordant male group compared to the discordant female group did not change whether its co-twin was of similar or opposite sex.
Discussion: Higher rate of MVM lesions characterizes growth discordant male neonates in DCDA twin gestations. This finding could represent a different adaptation of male fetuses to a hostile intrauterine environment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejogrb.2022.05.030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Counselling in Fetal Medicine: Uncomplicated Twin Pregnancies.
J Clin Med
December 2024
Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
Twin pregnancies account for 3% of all pregnancies and they are burdened by higher morbidity and mortality compared to singletons. The role of ultrasound in the screening, diagnosis and management of possible complications of twin pregnancies has been widely investigated in the current literature. However, despite the progress that have been made in the last decades regarding treatment and evidence-based management of complications, twin pregnancies remain at higher risk of adverse outcomes, requiring therefore dedicated surveillance.
View Article and Find Full Text PDFIs Fetal Reduction Necessary in Triplet Pregnancy? Single Tertiary Center Experience.
Fetal Pediatr Pathol
December 2024
Department of Obstetrics and Gynecology, Necmettin Erbakan University Medical School of Meram, Konya, Turkey.
Objective: This study aims to evaluate the perinatal outcomes of triplet pregnancies reduced from triplets to twins with fetal reduction (FR), followed expectantly without FR, and reduced to triplets from higher-order multiple pregnancies (HOMP) with FR.
Materials And Methods: Multifetal pregnancies followed at the university hospital in the last 8 years were evaluated retrospectively. The study group was composed of three groups.
Development and validation of an ultrasound-based estimated fetal weight reference for Chinese twin pregnancy: a retrospective cohort study.
BMC Pregnancy Childbirth
November 2024
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Article Synopsis
- This study focuses on the importance of monitoring fetal growth in twin pregnancies in China, where no clinically validated tools currently exist.
- Researchers developed chorionicity-specific growth charts for ultrasound estimated fetal weight (EFW) and validated them using a study from a tertiary hospital involving twin pregnancies delivered between 2007 and 2021.
- The results demonstrated significant differences in EFW between monochorionic and dichorionic twins, highlighting the need for tailored growth charts, and provided insights into neonatal outcomes based on different EFW classifications.
Perinatal outcomes of selective termination in dichorionic twin pregnancies: a retrospective study from a single center.
Arch Gynecol Obstet
October 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No.20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China.
Article Synopsis
- This study investigated the outcomes of selective termination (ST) in dichorionic diamniotic (DCDA) twin pregnancies, focusing on when the procedure occurred during gestation.
- Researchers analyzed data from 230 patients over a 10-year period, finding that earlier ST (before 18 weeks) led to better perinatal outcomes, including higher rates of term deliveries and live births.
- Despite some complications like preterm delivery and infections, no maternal deaths were reported, suggesting ST is a safe option for managing discordant fetal anomalies in DCDA twins when performed early.
The association of early pregnancy dyslipidemia with preterm birth in twin pregnancies: a retrospective cohort study.
BMC Pregnancy Childbirth
September 2024
Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, No.120, Longshan Rd, Chongqing, 401147, China.
Background: Maternal lipid metabolism has been implicated in elevating the risk of adverse pregnancy outcomes, which is a particularly significant concern in twin pregnancies. However, the precise relationship between early pregnancy dyslipidemia and the risk of preterm birth (PTB) in twin pregnancies remains unclear.
Methods: This retrospective cohort study included women with twin pregnancies between January 2018 and December 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!