Photoacoustic-triggered nanomedicine delivery to internal organs using a dual-wavelength laparoscope.

Precise drug delivery for internal organs is always an important clinical issue. In this study, we developed a dual-wavelength optical resolution photoacoustic laparoscope, and achieved precise and efficient delivery of nanomedicine to multiple abdominal organs. The laparoscope integrated 532 and 820 nm light to map the vascular network, and visually deliver the nanoparticles to the targeted area using photoacoustic radiation force, respectively. To achieve endoscopic use, we employed a micro-electro-mechanical-system (MEMS) scanner to realize internal two-dimensional raster scanning of the optical beams. Using phantom experiments, the lateral resolutions were measured as 3.75 μm for 532 nm, and 5.25 μm for 820 nm, respectively. Besides, we demonstrated the feasibility of targeted drug delivery using mouse-ear tumor model, normal organs, and colon tumor model. All the experimental results suggested that this strategy can serve as a promising precise drug delivery method for the effective treatment of internal organ diseases.