AI Article Synopsis
- The study aimed to compare conservative versus liberal oxygen therapy in ICU patients with non-hypoxic ischemic encephalopathy (HIE) to understand the effects on mortality and oxygen saturation levels.
- A post-hoc analysis of 217 patients from the ICU-ROX trial showed that those on conservative oxygen spent less time with high oxygen saturation levels, but there was no significant difference in mortality rates after 180 days between the two groups.
- The researchers concluded that further studies with a larger sample size are needed to confirm their findings regarding the effects of oxygen therapy on mortality rates in this patient population.
Article Abstract
Purpose: To compare the effect of conservative vs. liberal oxygen therapy in mechanically ventilated adults in the intensive care unit (ICU) with non-hypoxic ischemic encephalopathy (HIE) acute brain pathologies.
Materials And Methods: Post-hoc analysis of data from 217 patients with non-HIE acute brain pathologies included in the ICU Randomized Trial Comparing Two Approaches to OXygen therapy (ICU-ROX).
Results: Patients allocated to conservative oxygen spent less time with oxygen saturation ≥ 97% (50.5 [interquartile range (IQR), 18.5-119] vs. 82 h [IQR, 38-164], absolute difference, -31.5 h; 95%CI, -59.6 to -3.4). At 180 days, 38 of 110 conservative oxygen patients (34.5%) and 28 of 104 liberal oxygen patients (26.9%) had died (absolute difference, 7.6 percentage points; 95%CI, -4.7 to 19.9 percentage points; P = 0.23; interaction P = 0.02 for non-HIE acute brain pathologies vs. HIE; interaction P = 0.53 for non-HIE acute brain pathologies vs. non-neurological conditions).
Conclusions: In this post-hoc analysis, patients admitted to the ICU with non-HIE acute brain pathologies treated with conservative oxygen therapy did not have significantly lower mortality than those treated with liberal oxygen. A trial with adequate statistical power is needed to determine whether our day 180 mortality point estimate of treatment effect favoring liberal oxygen therapy indicates a true effect.
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| http://dx.doi.org/10.1016/j.jcrc.2022.154079 | DOI Listing |
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