AI Article Synopsis
- The study investigates the impact of adding corticosteroid (Dexamethasone) and Tocilizumab to standard treatments for COVID-19 patients with chronic diseases, focusing on lab biomarkers.
- The research involved 68 patients divided into four treatment groups, with the most notable results in the group receiving both Dexamethasone and Tocilizumab, showing significant changes in white blood cell counts and C-reactive Protein levels.
- Findings suggest that the combination of Dexamethasone and Tocilizumab may enhance treatment effectiveness for chronic disease patients suffering from COVID-19.
Article Abstract
Background And Aim: The most effective way to control severity and mortality rate of the novel coronavirus disease (COVID-19) is through sensitive diagnostic approaches and an appropriate treatment protocol. We aimed to identify the effect of adding corticosteroid and Tocilizumab to a standard treatment protocol in treating COVID-19 patients with chronic disease through hematological and lab biomarkers.
Materials And Methods: This study was performed retrospectively on 68 COVID-19 patients with chronic disease who were treated by different therapeutic protocols. The patients were categorized into four groups: control group represented the patients' lab results at admission before treatment protocols were applied; group 1 included patients treated with anticoagulants, Hydroxychloroquine, and antibiotics; group 2 comprised patients treated with Dexamethasone; and group 3 included patients treated with Dexamethasone and Tocilizumab.
Results: The WBC and neutrophil counts were increased significantly in group 3 upon the treatment when they were compared with patients in group 1 (p=0.004 and p=0.001, respectively). The comparison of C-reactive Protein (CRP) level at admission was higher in group 3 than in group 1 with p=0.030. After 10 days of treatment, CRP level was decreased in all groups, but in group 3 it was statistically significant (p=0.002).
Conclusion: The study paves the way into the effectiveness of combining Dexamethasone with Tocilizumab in treatment COVID-19 patients with chronic diseases.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035366 | PMC |
| http://dx.doi.org/10.1016/j.medcli.2022.02.013 | DOI Listing |
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