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Role of the androgen receptor in melanoma aggressiveness.
Cell Death Dis
January 2025
Department of Precision Medicine, University of Campania 'L. Vanvitelli'- Via L. De Crecchio 7, 80138, Naples, Italy.
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall survival and long-term disease containment. Nevertheless, the disease often progresses and becomes resistant to the therapies.
View Article and Find Full Text PDFChange in Patient Perceptions of Electronic Communication Methods for an Orthopaedic Fracture Clinic Between 2019 and 2024.
Cureus
November 2024
Trauma and Orthopaedics, Princess Royal University Hospital, King's College National Health Service (NHS) Foundation Trust, London, GBR.
Introduction Outpatient appointments are essential to patient care, yet rising non-attendance rates ('did not attend' DNAs) pose significant challenges, costing the National Health Service (NHS) over £1 billion annually. Traditional postal communication is inefficient and costly, while digital methods like short messaging service (SMS) and electronic mail (email) show the potential to improve attendance and reduce costs. This study investigates changes in patient preferences for orthopaedic outpatient communication methods between 2019 and 2024 at a busy district general hospital in London, UK.
View Article and Find Full Text PDFUsability and Effectiveness of eHealth and mHealth Interventions That Support Self-Management and Health Care Transition in Adolescents and Young Adults With Chronic Disease: Systematic Review.
J Med Internet Res
November 2024
Nursing Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: With advances in medical technologies, more children with chronic diseases are now living on into adulthood. The development of proficient self-management skills is essential for adolescents and young adults to transition from pediatric to adult health care services. An innovative way to improve the current care model and foster self-management skills could be through eHealth or mHealth (mobile health) interventions, in particular, when considering the rising ownership of digital technology by adolescents and young adults.
View Article and Find Full Text PDFSafety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial.
Lancet
November 2024
Department of Radiation Oncology, Duke University, Durham, NC, USA; Duke Cancer Institute, Durham, NC, USA; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:
Background: Approximately half of patients with localised, high-risk soft tissue sarcoma of the extremity develop metastases. We aimed to assess whether the addition of pembrolizumab to preoperative radiotherapy and surgery would improve disease-free survival.
Methods: We completed an open-label, randomised clinical trial in patients with grade 2 or 3, stage III undifferentiated pleomorphic sarcoma or dedifferentiated or pleomorphic liposarcoma of the extremity and limb girdle.
The impact of different forms of exercise on intraocular pressure, blood flow, and the risk for primary open angle glaucoma.
Eur J Ophthalmol
November 2024
Department of Ophthalmology, Icahn School of Medicine, New York, NY, USA.
Primary open angle glaucoma (POAG) is a chronic disease characterized by progressive optic nerve damage and irreversible loss of vision, often diagnosed at late stages. Elevated intraocular pressure (IOP) is the major risk factor for its onset and progression while older age, myopia, genetic factors, blood pressure (BP), and reduced ocular blood flow (OBF) have also been linked to the disease. Different forms of exercise are known to have significant, but variable, effects on IOP, BP, ocular perfusion pressure (OPP), OBF and oxygen metabolism, and ultimately the risk for development and progression of POAG.
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