Background: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease. Smaller sample size and complex nature of the disease pathogenesis has made it challenging to perform well-powered genetic investigations. We performed a systematic review based meta-analysis in GPA to investigate the genetic susceptibility conferred by non-human leukocyte antigen (non-HLA) candidate genes.
Methods: A systematic review was performed using web-based literature search and eligible studies were included following inclusion-exclusion criteria. Studies were evaluated for their quality of evidence and study outcome was assessed using the Newcastle-Ottawa Scale and Grades of Research, Assessment, Development and Evaluation tools. Reviewer's agreement was accessed through Cohen's κ value. Meta-analyses were performed using RevMan 5 tool. Meta-odds ratio (meta-OR) and Z test P value were evaluated to estimate the genetic susceptibility for each of the variants.
Results: Eighteen studies were found eligible and 7 genetic variants from only 4 genes, namely CTLA4, PRTN3, SERPINA1 and PTPN22 could be studied for meta-analysis. rs231775-G (49-G) (Meta-OR = 1.42 [1.14-1.76]; P = .001) of CTLA4 and rs7151526-A (Meta-OR = 2.70 [1.51-4.85]; P = .0008) of SERPINA1 were confirmed to be predisposing alleles, and rs5742909-C (318-C) (Meta-OR = 0.65 [0.44-0.97]; P =.03) of CTLA4 was found to be protective for GPA. In concordance with the genetic association of rs7151526-A, serological marker for the same variant "Z" allele of SERPINA1 was found to be predisposing (Meta-OR = 12.60 [5.01-31.68]; P < .00001) for GPA.
Conclusion: Genetic variants confirmed in this study play critical roles in T-cell mediated immune function and could be significantly implicated in GPA. Molecular pathology studies are warranted to confirm their role. These markers could be used for efficient patient classification and disease management.
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http://dx.doi.org/10.1111/1756-185X.14354 | DOI Listing |
BMC Genomics
December 2024
Department of Agricultural Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Background: Sugar beets (Beta vulgaris L.) are grown worldwide and suffer economic loss annually due to curly top disease caused by the beet curly top virus (BCTV). The virus is spread by the beet leafhopper (BLH), Circulifer tenellus Baker.
View Article and Find Full Text PDFBMC Microbiol
December 2024
Veterinary Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.
Background: Salmonella enterica is a major cause of foodborne illness and mortality worldwide, but its presence in milk along the milk supply chain and associated public health risks are under-studied. This research was aimed to investigate the occurrence and antimicrobial susceptibility of Salmonella enterica in milk, milking environments, milkers' hands, and diarrheic patients in Wolaita Sodo, Ethiopia.
Methods: We collected 644 samples from 106 dairy farms that include direct milk from cow, bulk tank milk, milkers' hand swabs, teat surfaces swabs, farm floors swabs, milk storage containers swabs, collectors' bulk milk, retailers' bulk milk, and stool from diarrheic patients.
Clin Rheumatol
December 2024
Immunology and Histocompatibility Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Introduction/objectives: Psoriatic arthritis (PsA) is a chronic inflammatory rheumatism belonging to the spondyloarthritis family. It is a multifactorial disease whose genetic determinism is still poorly understood. It is favored by environmental factors in genetically predisposed individuals.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
In this study, 10 fish species, Jayan flounder (Pseudorhombus javanicus); Oriental sole (Eurgglossa arientalis); Oange-spotted grouper (Epinephelus coioides); Blacktip trevally (Caranx heberi); Towbar seabream (Acanthopagrus bifascia); Smalltooth emperor (Lethrinus microdon); Spangled emperio (Lethrinus nebulous); Sharptooth hammer croaker (Johnius vogleri); Bigeye croaker (Pennahia anea) and Redspine thread bream (Nemipterus nemurus), were examined in El-Jubail province, Saudi Arabia, Arabian Gulf region over three years from 2017 to 2020. The examined fish species showed muscular atrophy in a total percent of 1.1%, but with variable percentages of affections in each species.
View Article and Find Full Text PDFIntroduction: The associations between sedentary lifestyles, physical activity and the risk of respiratory diseases are crucial areas of medical and health research. Despite numerous studies, uncertainties and controversies regarding causal relationships persist. We utilized Mendelian randomization (MR) analysis, an advanced statistical tool, to further investigate causal links.
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