AI Article Synopsis
- The study focused on the presence and types of Gram-negative bacteria in the nasopharynx of school children with acute otitis media in Banyumas Regency, Central Java, Indonesia.
- A high prevalence rate of 69.7% was found, with non-typeable strains being the most common.
- Most bacterial isolates showed susceptibility to various antibiotics, with a notable percentage resistant to cotrimoxazole and ampicillin.
Article Abstract
is a Gram-negative opportunistic bacterial pathogen of the human respiratory tract. This study describes the prevalence, serotype distribution, and susceptibility profiles of . strains isolated from the nasopharynx of school children with acute otitis media (AOM) in Banyumas Regency, Central Java, Indonesia. . was isolated from nasopharyngeal swab specimens using chocolate agar plates supplemented with IsoVitaleX and bacitracin. Serotyping was performed using quantitative polymerase chain reaction. Antimicrobial susceptibility profiles were determined using a microdilution broth assay. . was present in 69.7% of samples (85/122). Nontypeable . (NHTi) was the most common serotype (95.3%), followed by . type b (3.5%) and . type (1.2%). All the . isolates were susceptible to levofloxacin, ceftriaxone, imipenem, meropenem, cefuroxime, and cefixime. Most isolates were susceptible to sparfloxacin (99%), cefepime (99%), amoxicillin/clavulanic acid 2 : 1 (99%), ampicillin/sulbactam 2 : 1 (96%), chloramphenicol (94%), tetracycline (93%), ampicillin (87%), and clarithromycin (82%). Nineteen percent of the isolates were resistant to cotrimoxazole, and 11% of the isolates were resistant to ampicillin. This study showed that . carriage among samples was dominated by NTHi and less susceptible to cotrimoxazole.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152372 | PMC |
| http://dx.doi.org/10.1155/2022/5391291 | DOI Listing |
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