AI Article Synopsis
- The study investigated the incidence, risk factors, and outcomes of sepsis in critically ill patients who had undergone craniotomy, finding that 33.3% of the 900 patients developed sepsis.
- Advanced age, male gender, pre-existing hypertension, trauma history, postoperative intracranial complications, and lower Glasgow Coma Scale scores on the first day after surgery were identified as key risk factors for sepsis.
- Patients with sepsis experienced significantly higher mortality rates, longer stays in both the ICU and hospital, and increased medical costs compared to those without sepsis.
Article Abstract
Background: Data concerning the epidemiology of sepsis in critically ill post-craniotomy patients are scarce. This study aimed to assess the incidence, risk factors, and outcomes of sepsis in this population.
Methods: This was a single-center prospective cohort study. Post-craniotomy patients admitted to the intensive care unit (ICU) were screened daily for the presence of infection and sepsis.
Results: Of the 900 included patients, 300 developed sepsis. The cumulative incidence of sepsis was 33.3% [95% confidence interval (CI), 30.2-36.4%]. Advanced age, male, hypertension, trauma, postoperative intracranial complications, and lower Glasgow Coma Scale (GCS) on the first postoperative day were independent risk factors of sepsis. Septic patients had higher hospital mortality (13.7 vs. 8.3%, = 0.012), longer ICU length of stay (LOS) (14 vs. 4 days, < 0.001), longer hospital LOS (31 vs. 19 days, < 0.001), and higher total medical cost (CNY 138,394 vs. 75,918, < 0.001) than patients without sepsis.
Conclusion: Sepsis is a frequent complication in critically ill post-craniotomy patients. Advanced age, male, hypertension, trauma, postoperative intracranial complications, and lower GCS on the first postoperative day were independent risk factors of sepsis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152261 | PMC |
| http://dx.doi.org/10.3389/fpubh.2022.895991 | DOI Listing |
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