AI Article Synopsis
- Tachyarrhythmia treatments currently include drug therapy, catheter ablation, and implantable devices, but there's a need for more effective solutions as existing methods have limitations.
- Recent developments in gene therapy are being explored as a possible innovative approach for treating drug-refractory tachyarrhythmias.
- While gene therapy shows promise, further advancements are necessary to ensure safe and effective gene delivery for real-world use in clinical settings.
Article Abstract
Introduction: To date, the treatment option for tachyarrhythmia is classified into drug therapy, catheter ablation, and implantable device therapy. However, the efficacy of the antiarrhythmic drugs is limited. Although the indication of catheter ablation is expanding, several fatal tachyarrhythmias are still refractory to ablation. Implantable cardioverter-defibrillator increases survival, but it is not a curable treatment. Therefore, a novel therapy for tachyarrhythmias refractory to present treatments is desired. Gene therapy is being developed as a promising candidate for this purpose, and basic research and translational research have been accumulated in recent years.
Areas Covered: This paper reviews the current state of gene therapy for arrhythmias, including susceptible arrhythmias, the route of administration to the heart, and the type of vector to use. We also discuss the latest progress in the technology of gene delivery and genome editing.
Expert Opinion: Gene therapy is one of the most promising technologies for arrhythmia treatment. However, additional technological innovation to achieve safe, localized, homogeneous, and long-lasting gene transfer is required for its clinical application.
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| http://dx.doi.org/10.1080/14779072.2022.2085686 | DOI Listing |
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