AI Article Synopsis
- Since 2019, COVID-19 has infected hundreds of millions globally, highlighting the importance of developing vaccines in response to variants and vaccine-induced immunity issues.
- A new recombinant plant-derived vaccine, CoVLP, and a variant-targeted version, CoVLP.B1351, have shown promise in mouse studies to elicit strong immune responses against various COVID-19 variants.
- Both vaccination approaches generated robust neutralizing antibodies, with a slight advantage for the heterologous prime-boost strategy over the traditional one.
Article Abstract
Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulting in the coronavirus disease 2019 (COVID-19) has afflicted hundreds of millions of people in a worldwide pandemic. Several safe and effective COVID-19 vaccines are now available. However, the rapid emergence of variants and risk of viral escape from vaccine-induced immunity emphasize the need to develop broadly protective vaccines. A recombinant plant-derived virus-like particle vaccine for the ancestral COVID-19 (CoVLP) recently authorized by Canadian Health Authorities and a modified CoVLP.B1351 targeting the B.1.351 variant (both formulated with the adjuvant AS03) were assessed in homologous and heterologous prime-boost regimen in mice. Both strategies induced strong and broadly cross-reactive neutralizing antibody (NAb) responses against several Variants of Concern (VOCs), including B.1.351/Beta, B.1.1.7/Alpha, P.1/Gamma, B.1.617.2/Delta and B.1.1.529/Omicron strains. The neutralizing antibody (NAb) response was robust with both primary vaccination strategies and tended to be higher for almost all VOCs following the heterologous prime-boost regimen.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135691 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2022.05.046 | DOI Listing |
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