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Biomarkers of heatstroke-induced organ injury and repair. | LitMetric

Biomarkers of heatstroke-induced organ injury and repair.

Exp Physiol

Department of Experimental Medicine, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

Published: October 2022

AI Article Synopsis

  • - The review focuses on identifying novel biological markers (biomarkers) to assess the risk of organ injury and long-term complications in heatstroke patients.
  • - It highlights advancements in recognizing various biomarkers related to cellular injury and tissue damage across different organ systems affected by heatstroke, including cardiovascular, renal, cerebral, intestinal, and skeletal muscle injuries.
  • - The review notes that while many biomarkers have been identified for different organs, no new specific biomarkers have been found for liver or lung injuries related to heatstroke.

Article Abstract

New Findings: What is the topic of this review? The status and potential role of novel biological markers (biomarkers) that can help identify the patients at risk of organ injury or long-term complications following heatstroke. What advances does it highlight? Numerous biomarkers were identified related to many aspects of generalized heatstroke-induced cellular injury and tissue damage, and heatstroke-provoked cardiovascular, renal, cerebral, intestinal and skeletal muscle injury. No novel biomarkers were identified for liver or lung injury.

Abstract: Classic and exertional heatstroke cause acute injury and damage across numerous organ systems. Moreover, heatstroke survivors may sustain long-term neurological, cardiovascular and renal complications with a persistent risk of death. In this context, biomarkers, defined as biological samples obtained from heatstroke patients, are needed to detect early organ injury, and predict outcomes to develop novel organ preservation therapeutic strategies. This narrative review provides preliminary insights that will guide the development and future utilization of these biomarkers. To this end, we have identified numerous biomarkers of widespread heatstroke-associated cellular injury, tissue damage and repair (extracellular heat shock proteins 72 and 60, high mobility group box protein 1, histone H3, and interleukin-1α), and other organ-specific biomarkers including those related to the cardiovascular system (cardiac troponin I, endothelium-derived factors, circulation endothelial cells, adhesion molecules, thrombomodulin and von Willebrand factor antigen), the kidneys (plasma and urinary neutrophil gelatinase-associated lipocalin), the intestines (intestinal fatty acid-binding protein 2), the brain (serum S100β and neuron-specific enolase) and skeletal muscle (creatine kinase, myoglobin). No specific biomarkers have been identified so far for liver or lung injury in heatstroke. Before translating the identified biomarkers into clinical practice, additional preclinical and clinical prospective studies are required to further understand their clinical utility, particularly for the biomarkers related to long-term post-heatstroke health outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529995PMC
http://dx.doi.org/10.1113/EP090142DOI Listing

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