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http://dx.doi.org/10.1016/j.hrthm.2022.05.031 | DOI Listing |
Int J Mol Sci
February 2025
Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, 1431 Sofia, Bulgaria.
Diabetic neuropathy (DN) is characterized by nerve damage as a consequence of diabetes mellitus. Diabetes causes high blood glucose and triglyceride levels, which destroy the nerve blood vessels over time and trigger DN. Peripheral neuropathy is the most common type of DN, which encompasses a broad range of symptoms.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
School of Nursing, Peking University, Beijing 100191, China.
Diabetes-related cognitive impairment (DCI) is a severe complication of type 2 diabetes mellitus (T2DM), with limited understanding of its molecular mechanisms hindering effective therapeutic development. This study identified SERPINA3 as a potential therapeutic target for DCI through integrated machine learning and molecular docking analyses. Transcriptomic data from cortical neuronal samples of T2DM patients were analysed using support vector machine recursive feature elimination (SVM-RFE) and least absolute shrinkage and selection operator (LASSO) regression, revealing SERPINA3 as a significantly upregulated gene in DCI.
View Article and Find Full Text PDFMolecules
February 2025
3D Printing Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.
Lidocaine is an analgesic agent frequently incorporated in topical formulations intended for application in minor surgical procedures or relieving neuropathic pain associated with numerous conditions, including post-herpetic neuralgia or diabetic peripheral neuropathy. In this study, Pickering o/w emulsions with halloysite nanotubes as a stabilizing agent and lidocaine incorporated in the internal phase were formulated with the use of the Quality by Design (QbD) approach. The selected emulsions were transformed into semisolid gels with poloxamer 407 as a thickening agent, and investigated for rheological and textural properties, indicating the mechanical features of the obtained gels.
View Article and Find Full Text PDFAnal Chim Acta
May 2025
Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, Wageningen, 6708 WE, the Netherlands; Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, Wageningen, 6708 WB, the Netherlands. Electronic address:
Background: Atropine is a strictly regulated natural toxin. Monitoring for atropine is thus important, but often expensive and time-consuming. Moreover, the range of relevant matrices, and corresponding differences in required detection limits for atropine vary.
View Article and Find Full Text PDFCells
March 2025
Department of Pathology, Hebei Medical University, Shijiazhuang 050017, China.
Diabetic kidney disease (DKD) is a prevalent complication associated with diabetes in which podocyte dysfunction significantly contributes to the development and progression of the condition. Ring finger protein 183 (RNF183) is an ER-localized, transmembrane ring finger protein with classical E3 ligase activity. However, whether RNF183 is involved in glomerular podocyte dysfunction, which is the mechanism of action of DKD, is still poorly understood.
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