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Deficiency of purinergic P2Y2 receptor impairs the recovery after renal ischemia-reperfusion injury and accelerates renal fibrosis and tubular senescence in mice.
Sci Rep
December 2024
Department of Pharmacology, Institute of Health Sciences, Gyeongsang National University College of Medicine, 15, 816 Beon-gil, Jinjudaero, Jinju, 52727, Republic of Korea.
Chronic kidney disease is defined as a progressive loss of kidney function associated with impaired recovery after acute kidney injury. Renal ischemia-reperfusion (IR) induces oxidative stress and inflammatory responses leading to severe tissue damage, where incomplete or maladaptive repair accelerates renal fibrosis and aging. To investigate the role of the purinergic P2Y2 receptor (P2Y2R) in these processes, we used P2Y2R knockout (KO) mice subjected to IR.
View Article and Find Full Text PDFModification of Fc-fusion protein structures to enhance efficacy of cancer vaccine in plant expression system.
Plant Biotechnol J
December 2024
BioSystems Design Lab, Department of Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
Epithelial cell adhesion molecule (EpCAM) fused to IgG, IgA and IgM Fc domains was expressed to create IgG, IgA and IgM-like structures as anti-cancer vaccines in Nicotiana tabacum. High-mannose glycan structures were generated by adding a C-terminal endoplasmic reticulum (ER) retention motif (KDEL) to the Fc domain (FcK) to produce EpCAM-Fc and EpCAM-FcK proteins in transgenic plants via Agrobacterium-mediated transformation. Cross-fertilization of EpCAM-Fc (FcK) transgenic plants with Joining chain (J-chain, J and JK) transgenic plants led to stable expression of large quaternary EpCAM-IgA Fc (EpCAM-A) and IgM-like (EpCAM-M) proteins.
View Article and Find Full Text PDFThe protective effect of the vagus nerve-α7nAChR-IL-22 pathway on acute liver injury.
Cytokine
December 2024
Department of Hepatobiliary & Hydatid Disease, Digestive & Vascular Surgery Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, China. Electronic address:
Article Synopsis
- The study investigates the role of the vagus nerve's α7nAChR receptor in regulating interleukin-22, which may help mitigate acute liver injury.
- Carbon tetrachloride was used to induce liver injury in rat models and human liver cells, revealing that interfering with α7nAChR leads to higher liver damage markers like AST and ALT.
- The findings suggest that enhancing vagus nerve activity and interleukin-22 levels can aid liver recovery, while blocking these pathways may worsen liver injury.
Epidermal stem cell-derived exosomes improve wound healing by promoting the proliferation and migration of human skin fibroblasts.
Burns Trauma
December 2024
Department of Burn and Plastic Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, 1 Panfu Road, Yuexiu District, Guangzhou City, Guangdong Province, 510180, China.
Background: Epidermal stem cells (ESCs) are primarily located in the basal layer of the epidermis and play a crucial role in wound healing. ESCs-derived exosomes (ESCs-Exo) are emerging as promising candidates for skin regeneration and wound healing. However, the underlying mechanisms remain unclear.
View Article and Find Full Text PDFHigh mobility group protein N2 inhibits the progression of hepatocellular carcinoma and the related molecular mechanisms.
Cytotechnology
February 2025
Department of Hepatobiliary Vascular Surgery, Chengdu Seventh People's Hospital, Chengdu, 610000 China.
High mobility group protein N2 (HMGN2) related pathways are involved in chromatin regulation/acetylation. It has been reported to be involved in several types of cancers. A recent sequencing study suggested that HMGN2 might be involved in the progression of hepatocellular carcinoma (HCC).
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