The purpose of this study was to report approaches to surgical and medical management of proximal tibial metaphyseal fractures (PTMF) and short-term case outcome. Medical records of immature dogs with PTMF were reviewed and data were collected including history, signalment and side affected. Data pertaining to surgical and medical management including radiographic evaluation and short-term complications were recorded. Forty-five dogs with a total of 47 PTMF identified and treated between 2007-2019 were included in this study. Six cases were managed with external coaptation alone. Forty-one cases were treated surgically with constructs including K-wires in different configurations, bone plate and screws, and external skeletal fixation. Of the cases managed conservatively, 4 developed complications, including bandage sores, diffuse osteopenia of the tarsus/metatarsus, and angular limb deformities. Surgical complications including pin migration necessitating removal, osteopenia, and screw placement in the proximal tibial growth plate or into the stifle joint were found in 16 cases. PTMF treated with surgery had a subjectively more predictable outcome compared to those treated with external coaptation alone. Conservative management may result in complications including development of excessive tibial plateau angle (TPA) as well as distal tibial valgus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162371 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268378 | PLOS |
Retina
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Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
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J Am Acad Orthop Surg Glob Res Rev
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From the Department of Orthopaedics and Sports Medicine, Mercy Health St. Vincent Medical Center, Toledo, OH (Dr. Simmons); the Department of Orthopedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH (Dr. Vesselle); the Department of Orthopaedic Surgery, MetroHealth Medical Center, Cleveland, OH (Dr. Yildirim, Dr. Bafus); the Town Center Orthopaedics, Reston, VA (Dr. Yildirim); and the Louis Stokes Cleveland VA Medical Center, Cleveland, OH (Dr. Bafus).
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View Article and Find Full Text PDFAm J Phys Med Rehabil
January 2025
Department of Clinical Psychology, International Institute of Behavioural Medicine, Seville, Spain.
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Proc Natl Acad Sci U S A
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Department of Molecular & Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267.
TGFβ family ligands are synthesized as precursors consisting of an N-terminal prodomain and C-terminal growth factor (GF) signaling domain. After proteolytic processing, the prodomain typically remains noncovalently associated with the GF, sometimes forming a high-affinity latent procomplex that requires activation. For the TGFβ family ligand anti-Müllerian hormone (AMH), the prodomain maintains a high-affinity interaction with its GF that does not render it latent.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Perianal fistulas (PAFs) are a severe complication of Crohn's disease that significantly impact patient prognosis and quality of life. While stem-cell-based strategies have been widely applied for PAF treatment, their efficacy remains limited. Our study introduces an injectable, temperature-controlled decellularized adipose tissue-alginate hydrogel loaded with dental pulp mesenchymal stem cells (DPMSCs) for in vivo fistula treatment.
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