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Evaluation of medicine use behaviors of adult patients in a rural area: A cross-sectional study from Turkey.
J Family Med Prim Care
December 2024
Güneysu Tenzile Erdogan District Hospital, Rize, Turkey.
Background/purpose: This study aimed to determine the medicine usage behaviors of patients (>65 years) registered to the family health care center (FHCC) in a rural area.
Methods: This cross-sectional and descriptive study was performed on 224 geriatric patients admitted to the FHCC in Terme town of Samsun between January 2018 and March 2018. The questionnaire consisting of 29 questions about sociodemographic characteristics, knowledge of drugs, and usage habits was applied to the participants by using the face-to-face interview technique.
Classifying and Characterising Unmet Integrated Care Needs of Older Adults With Multimorbidity: A Latent Profile Analysis.
J Clin Nurs
January 2025
Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Aims: To classify the unmet integrated care needs of older adults with multimorbidity and to explore the factors associated with different categories of unmet integrated care needs among the target population.
Design: A cross-sectional survey using the statistical method of latent profile analysis.
Methods: From July 2022 to March 2023, 397 older adults with multimorbidity, aged 60 years or older, were recruited from one primary healthcare setting and from four secondary and tertiary hospitals to participate in face-to-face questionnaire surveys.
Rational Synthesis of Highly Fluorescent N, S Co-Doped Carbon Dots Using Biogenic Creatinine for Cu Analysis in Drinking Water.
Luminescence
January 2025
Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Herein, highly fluorescent sulfur and nitrogen co-doped carbon dots (N, S-CDs) had been employed as a fluorescent probe to analyze Cu in drinking water. The biogenic creatinine is known to form a stable complex with Cu; hence, it was rationally selected as a bioinspired nitrogen substrate for the first time to enhance N, S-CDs selectivity towards Cu. Moreover, the literature was surveyed to guide the selection of sulfur and carbon sources to optimize N, S-CDs quantum yield (QY), so thiourea and disodium edetate are co-carbonized with biogenic creatinine at 270°C for 40 min and characterized using different techniques.
View Article and Find Full Text PDFParallel Temperature Replica-Exchange Molecular Dynamics Simulations Capture the Observed Impact of Stapling on Coiled-Coil Conformational Stability.
J Phys Chem B
January 2025
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, United States.
Macrocyclization or stapling is an important strategy for increasing the conformational stability and target-binding affinity of peptides and proteins, especially in therapeutic contexts. Atomistic simulations of such stapled peptides and proteins could help rationalize existing experimental data and provide predictive tools for the design of new stapled peptides and proteins. Standard approaches exist for incorporating nonstandard amino acids and functional groups into the force fields required for MD simulations and have been used in the context of stapling for more than a decade.
View Article and Find Full Text PDFSelecting Initial Conditions for Trajectory-Based Nonadiabatic Simulations.
Acc Chem Res
January 2025
Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom.
ConspectusPhotochemical reactions have always been the source of a great deal of mystery. While classified as a type of chemical reaction, no doubts are allowed that the general tenets of ground-state chemistry do not directly apply to photochemical reactions. For a typical chemical reaction, understanding the critical points of the ground-state potential (free) energy surface and embedding them in a thermodynamics framework is often enough to infer reaction yields or characteristic time scales.
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