AI Article Synopsis
- The study aims to evaluate the effects of isoflavone supplementation on menopausal symptoms and ovarian hormones in postmenopausal women, as previous research has produced mixed results.
- A systematic review and meta-analysis of 11 randomized controlled trials found that isoflavones significantly increased estradiol levels and improved the Kupperman index but did not significantly impact hot flashes or certain hormonal levels.
- The authors caution that while the findings are promising, high variability among studies suggests the need for larger trials to confirm the results.
Article Abstract
Background/objectives: Complementary and alternative medicines can be used to alleviate climacteric symptoms that significantly affect the quality of life of postmenopausal women. Isoflavones are the most common plant-based therapies for postmenopausal changes, but the results of previous studies have been controversial.
Materials/methods: To investigate whether isoflavones would affect menopausal symptoms as well as ovarian hormones, we performed a systematic review and meta-analysis. The PubMed and EMBASE databases were used to perform the systematic search. Included studies were limited to randomized controlled trials (RCTs) assessing the impact of isoflavone supplementation on menopausal symptoms.
Results: Eleven studies were included for the final quantitative assessment. Isoflavone intervention was varied between 49.3 and 135 mg of isoflavones per day for 12 wk-2 yrs. The meta-analysis showed that supplementation of isoflavones significantly increased the estradiol levels (standardized mean difference [SMD] = 0.615, = 0.035) and Kupperman index (SMD = 3.121, = 0.003) but had no significant effect on hot flashes, follicle-stimulating hormone, and luteinizing hormone. However, both estradiol and the Kupperman index showed significant heterogeneity among studies (I = 94.7%, < 0.001 and I = 98.1%, < 0.001, respectively).
Conclusions: Although the results showed a significant SMD in estradiol and the Kupperman index, the results should be interpreted with caution due to the high heterogeneity. Further validation with a larger RCT will be necessary. Overall, isoflavone supplementation has distinct effects on the climacteric symptoms and hormonal changes in postmenopausal women.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127519 | PMC |
| http://dx.doi.org/10.4162/nrp.2022.16.S1.S147 | DOI Listing |
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