AI Article Synopsis
- Thyroid storm (TS) is a serious medical emergency mostly triggered by Graves' disease (GD), and can occur after immune reconstitution therapy with the drug alemtuzumab in patients with multiple sclerosis.
- A case is highlighted involving a 39-year-old woman who developed TS due to GD triggered by alemtuzumab, and she was treated with antithyroid medications followed by a thyroidectomy.
- There is some evidence suggesting that GD caused by alemtuzumab may be less aggressive than typical GD, but it's crucial for doctors to be vigilant about the risk of severe complications like TS, which necessitate quick treatment.
Article Abstract
Thyroid storm (TS) is a rare and life-threatening medical emergency, most commonly caused by Graves' disease (GD). GD can be induced by immune reconstitution therapy (IRT) such as alemtuzumab (ALZ), a humanized monoclonal antibody against CD52, which is shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Here, we present a rare case of TS developing in a 39-year-old female with ALZ-induced GD, managed with antithyroid medication followed by thyroidectomy. There is some evidence that ALZ-induced GD may behave less aggressively than conventional GD. However, physicians should be aware that severe thyrotoxicosis and thyroid storm can happen, which requires prompt recognition and aggressive therapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138563 | PMC |
| http://dx.doi.org/10.7759/cureus.24570 | DOI Listing |
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