Time-gated reflection matrix (RM) has been successfully used for optical imaging deep inside scattering media. Recently, this method was extended to enhance the spatiotemporal focusing of light ultra-deep inside scattering media. This is achieved by calibrating the decomposition of the RM with the Tikhonov regularization parameter to convert multiply scattered photons that share the same time of flight with the singly scattered photons into singly scattered photons. Such a capability suggests a reshaping to the interaction mechanism between light and scattering media, which may benefit or inspire wide optical applications that desire enhanced spatiotemporal focusing of light at depths inside scattering media.
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http://dx.doi.org/10.1038/s41377-022-00858-w | DOI Listing |
Carbohydr Polym
March 2025
Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan. Electronic address:
This study aims to explore the development of natural bio-based amphiphilic block copolymers for drug delivery applications. We investigated block copolymers derived from tamarind seed xyloglucan and solanesol, focusing on their synthesis, structural analysis, aqueous self-assembly, and drug encapsulation. Specifically, xyloglucan hydrolysate segments with number-average degrees of polymerization (DPs) of between 8 and 44 (XOS, XMS, XMS, XMS, and XMS) were used as the hydrophilic blocks, whereas plant-sourced solanesol was selected as the hydrophobic segment.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
Laboratoire Ondes et Milieux Complexes LOMC UMR CNRS 6294, Université Le Havre Normandie, 75 rue Bellot, Le Havre, France.
Inhomogeneous media made of random configurations of coated circular cylinders are considered. The effective properties-wave number, mass density, bulk modulus-are discussed and illustrated. The effects of the volume fraction of the scatterers and surrounding fluid are also examined.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Electronic address:
Genetically engineered immune cells hold great promise for treating immune-related diseases, but their development is hindered by technical challenges, primarily related to nucleic acid delivery. Polyethylenimine (PEI) is a cost-effective transfection agent, yet it requires significant optimization for effective T cell transfection. In this study, we comprehensively fine-tuned the characteristics of PEI/DNA nanoparticles, culture conditions, cellular physiology, and transfection protocols to enhance gene delivery into T cells.
View Article and Find Full Text PDFJ Nanobiotechnology
January 2025
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, China.
Background: Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stability. However, its clinical application for in vivo imaging is limited by the inherently weak Raman scattering signal.
View Article and Find Full Text PDFHypothesis: The oil phase controls the persistence length and aqueous channel diameter of reverse wormlike micelles (RWLMs), specifically by tuning the cohesive energy density of alkanes.
Experiments: We explore the influence of alkanes with varying chain lengths on the rheological properties, structural parameters, and morphology of RWLMs. To establish a link between the solvent characteristics and the structure of RWLMs, we employ a diverse set of complementary techniques, including rheological analysis, small-angle X-ray scattering (SAXS), Fourier-transform infrared (FT-IR) spectroscopy, and cryogenic transmission electron microscopy (cryo-TEM).
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